Diaphyseal giant cell-rich osteosarcoma: Unusual histological variant in an unusual site

Kinra, Prateek; Valdamani, Srinivas; Singh, Vikram; Dutta, Vibha

doi:10.4103/0377-4929.107848

Cited by 9 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the GCRO has conceded as high-grade conventional osteosarcoma as well, this variant also has the therapeutic and prognostic significance also, so this case seemed obvious to report it [10]. Although, the role of the presence of osteoclast-like giant cells is still not clear in the extent of prognosis.…”

Section: Discussionmentioning

confidence: 88%

Unusual and Aggressive Course of Giant Cell-Rich Osteosarcoma of Femur: A Case Report

Mishra¹,

Baduke²,

Khare³

et al. 2020

IJCR

View full text Add to dashboard Cite

Primary tumors of bones are rare and composed of around 0.2% of the total load of tumors in humans. Among primary tumors, osteosarcoma is the most common primary non-hematopoietic malignancy. Giant cell-rich osteosarcoma (GCRO) is a rarest histologic variant and comprised of only 1-3% of the total burden of conventional osteosarcoma. Here, we present the case of a 16-year-old female patient with complaints of pain in the left distal thigh for 3 weeks and swelling for 1 week. The X-ray showed the lytic lesions, with a wide zone of transition over the meta-diaphyseal distal femur with a pathological fracture in the supracondylar area and Codman's triangle. Further investigation revealed the diagnosis of GCRO with the proximal tibia and lung metastasis. The prognosis was explained and radical amputation was planned in the form of above-knee amputation. However, in the post-operative period and before the commencement of the adjuvant therapy, the patient became dyspneic and her Glasgow coma scale started deteriorated and unfortunately, she could not be revived.

show abstract

Section: Discussionmentioning

confidence: 88%

Unusual and Aggressive Course of Giant Cell-Rich Osteosarcoma of Femur: A Case Report

Mishra¹,

Baduke²,

Khare³

et al. 2020

IJCR

View full text Add to dashboard Cite

show abstract

“…The term ‘giant cell-rich osteosarcoma’ is reserved for those osteosarcomas that contain abundant osteoclast-like giant cells distributed throughout the tumor. [ 2 5 ] At low-power view, these lesions show multinucleated giant cells simulating a GCT; but on high-power view, cytologic anaplasia of the stromal cells and malignant osteoid production can usually be identified. [ 5 ] The tumor cells show nuclear pleomorphism and are usually mitotically active.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 5 ] At low-power view, these lesions show multinucleated giant cells simulating a GCT; but on high-power view, cytologic anaplasia of the stromal cells and malignant osteoid production can usually be identified. [ 5 ] The tumor cells show nuclear pleomorphism and are usually mitotically active. [ 2 ] The giant cells are seen scattered within the lesion.…”

Section: Discussionmentioning

confidence: 99%

Solid variant of aneurysmal bone cyst presenting as a giant cervical mass: A clinical, radiological, histopathological dilemma

Savardekar¹,

Patra²,

Chatterjee³

et al. 2015

Surg Neurol Int

View full text Add to dashboard Cite

Background:Typical aneurysmal bone cysts (ABCs) are osteolytic, multicystic lesions with parietal sclerosis and blood-filled cysts. In rare instances, the cystic components may be completely absent. Such solid variants in ABC (s-ABC) exhibit a solid architecture; making the clinical, radiological, and histological differentiation from other solid bone tumors like osteosarcoma (especially giant cell rich osteosarcoma) and giant cell tumor, a difficult task.Case Report:We report the case of a 45–year-old male presenting with a giant solid cervical spine lesion. Histopathology revealed solid variant of ABC, even though the radiological and fine needle aspiration cytology studies pointed toward a giant cell tumor.Conclusion:We aim to discuss the clinical, radiological, and histological findings of solid ABC (a rare benign entity) vis-à-vis the common neoplastic entities of osteosarcoma and giant cell tumor. The histopathological nuisances in making the diagnosis of s-ABC are put forth, along with its impact on management of such giant bony spinal lesions.

show abstract

“…In addition, there usually is a great deal of nuclear pleomorphism evident in telangectatic osteosarcomas, which will help to differentiate it from aneurismal bone cyst. [6] In Small cell osteosarcoma, radiologic features are not consistently typical for osteosarcoma because there often is very little mineralized matrix produced. Histologically it may be mistaken for Ewing sarcoma/primitive neuroectodermal tumor because its cells are small and have round, hyperchromatic nuclei with very little nuclear pleomorphism characteristic of conventional high grade osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Diaphyseal osteosarcoma with varying histomorphologic patterns

et al. 2014

View full text Add to dashboard Cite

Osteosarcoma is the most common primary malignant tumor of the skeleton involving predominantly metaphysis of the long bones. Diaphyseal osteosarcoma is a rare form, which accounts for approximately 10% of all cases of osteosarcomas. Osteosarcoma contains a family of lesions with considerable diversity in histologic features and grade. We present a case of a 29-year-old male with diaphyseal osteosarcoma of the left tibia, who presented with pain and swelling over middle one-third of the left leg. The biopsy of the lesion revealed varied histomorphologic features in a small tissue studied. This prompted us to report the various histologic patterns of osteosarcoma.

show abstract

Diaphyseal giant cell-rich osteosarcoma: Unusual histological variant in an unusual site

Cited by 9 publications

References 7 publications

Unusual and Aggressive Course of Giant Cell-Rich Osteosarcoma of Femur: A Case Report

Unusual and Aggressive Course of Giant Cell-Rich Osteosarcoma of Femur: A Case Report

Solid variant of aneurysmal bone cyst presenting as a giant cervical mass: A clinical, radiological, histopathological dilemma

Diaphyseal osteosarcoma with varying histomorphologic patterns

Contact Info

Product

Resources

About