Diarrhea in Children of West Pakistan: Occurrence of Bacterial and Parasitic Agents *

Ingram, Virginia G.; Rights, Fred L.; Khan, Hina; Hashimi, Kaukab; Ansari, Kamar

doi:10.4269/ajtmh.1966.15.743

Cited by 22 publications

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“…Rendtorff (1954) showed in prison volunteers that G. lamblia alone produced diarrhoea. Studies from Asia have shown that the parasite is found much more commonly in subjects with diarrhoea than in asymptomatic ,subjects (Ingram et al, 1966;Antia et al, 1966). Antia et al (1966) showed further that G. lamblia was present in only 5 5% of persons with miscellaneous gastrointestinal symptoms or in 6-7 % of subjects with dysentery-that is, diarrhoea with blood in the stools, a symptom not noted in giardiasis.…”

Section: Discussionmentioning

confidence: 99%

“…Giardia lamblia, a flagellate protozoan parasite of the human upper small bowel, is commonly associated with diarrhoea in the tropics (Antia et al, 1966;Ingram et al, 1966;Kapoor and Mody, 1968), though symptomatic giardiasis is reported from temperate areas (Moore et al, 1969;Brodsky et al, 1974;Brady and Wolfe, 1974). The most common symptoms reported are abdominal discomfort, abdominal distension, diarrhoea with soft, offensive, yellow stools, and lassitude.…”

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confidence: 99%

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Giardiasis: clinical and therapeutic aspects.

Wright¹,

Tomkins²,

Ridley³

1977

Gut

122

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SUMMARY Malabsorption was present in 29 of 40 symptomatic patients with giardiasis. Twentythree had impaired D-xylose absorption; in 20 vitamin B12 absorption was low, and 15 patients had steatorrhoea. More severe malabsorption was associated with more marked histological abnormalities. Metronidazole, 2-0 g as a single daily dose on three successive days, produced a parasitological cure rate of 91%. In contrast, the standard course of mepacrine, 100 mg thrice daily for 10 days, eradicated the parasite in only 63% of patients. Improvements in absorption and jejunal morphology followed anti-giardial treatment. Tetracycline in eight patients failed to eradicate the parasite, intestinal absorption was unaltered, and histological appearances of the jejunal mucosa often deteriorated.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Giardiasis: clinical and therapeutic aspects.

Wright¹,

Tomkins²,

Ridley³

1977

Gut

122

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“…Alternatively, the following may be employed: (1) tetracycline (as oxytetracycline or chlortetracycline) 250 mg, 6-hourly for 10 days, plus (2) diloxanide furoate, 0-5 g. thrice daily for 10 days, plus (3) chloroquine, 600 mg initially, followed by 300 mg six hours later and then 150 mg twice daily for 14 days.20…”

Section: Complicationsmentioning

confidence: 99%

Dysentery including amoebiasis.

Hendrickse¹

1973

BMJ

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Enteritis Due to "Related Vibrio" in Children

Cadranel¹

1973

Arch Pediatr Adolesc Med

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A "related Vibrio" was found in numerous stool cultures from a 16-month-old boy with chronic diarrhea. An outbreak of acute diarrhea occurred in the nursery frequented by this boy; the same Vibrio was isolated in the stool cultures of all symptomatic cases. Using a new device, the related Vibrio has also been isolated in intestinal aspirates at different levels of the gastrointestinal tract in several cases.Slight changes were observed in the jejunal mucosa of the child with chronic diarrhea.Infecti on of cattle by Vibrio fetus is well documented. In man, the infection is infrequent: in a re¬ cent review of the literature,1 it was found recorded 79 times. A serologically distinct species, named "related Vibrio," was identified only in blood Fig 1.-Light microscopy of jejunal mu¬ cosa in reported case; slight shortening and broadening of villi but surface epithelium appears normal (original magnification x 150). cultures, first in four children with enteritis-and subsequently in five children and two adults with diar¬ rhea.'" The first isolation of the re¬ lated Vibrio in stool cultures of two adults was reported recently.7 Following the same technique, one of us (J. P. B.) systematically searched for the related Vibrio in stool cultures and found 58 new cases.8We report positive stool cultures for the related Vibrio in a child who had intermittent diarrhea for several months and in 15 cases from the same community presenting as acute diar¬ rhea. The same strain was isolated in gastric, jejunal, and ileal aspirates from some of them.A 16-month-old boy was admitted to our department with diarrhea which had be¬ gun when he entered a public nursery two months earlier. Family history is irrele¬ vant; the child was born normally and his birth weight w~s 2,750 gm. At the age of 12 months his height and weight corre¬ sponded to the third percentile for the local population.9At 16 months his height had followed the same percentile, but his weight remained unchanged. The child had no fever and did not vomit, but passed three to five yellow¬ ish, soft, bulky stools each day. Except for pallor and underweight, the physical ex¬ amination results were normal. Serum con¬ centration of sodium, potassium, chloride, calcium, phosphorus, alkaline phosphatases, urea, creatinine, total protein, and paper electrophoresis of protein were all within normal limits, as well as total lipids, cholesterol, carotene, and immunoglobulins.The hemoglobin concentration of 10 gm/100 ml, red blood cell count of Downloaded From: http://archpedi.jamanetwork.com/ by a Oakland University User on 06/05/2015

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Diarrhea in Children of West Pakistan: Occurrence of Bacterial and Parasitic Agents *

Cited by 22 publications

References 0 publications

Giardiasis: clinical and therapeutic aspects.

Giardiasis: clinical and therapeutic aspects.

Dysentery including amoebiasis.

Enteritis Due to "Related Vibrio" in Children

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