Diarrhées aiguës infectieuses

Carré, Dominique; Debonne, Jean-Marc; Chapalain, J. C.; Klotz, F.

doi:10.1016/s1166-8598(00)00042-9

Cited by 3 publications

(3 citation statements)

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“…These signs are typical of infectious or 'invasive' diarrhea. [27] Intestinal fermentation in diarrheic rats, by reducing the pH and increasing faecal bulk, [28] raised the faeces frequency. Sd1 swarming is responsible for shiga toxin production, which induces the production of an important reactive oxygen metabolite, the mediator nitric oxide (NO), which is implicated in the inflammation associated with diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Activity of aqueous ethanol extract of Euphorbia prostrata ait on Shigella dysenteriae type 1-induced diarrhea in rats

et al. 2007

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Aim: Aim: Euphorbia prostrata (Euphorbiaceae) is traditionally used in Cameroon for the treatment of many diseases, including diarrhea. We investigated the acute toxicity and effect of the aqueous ethanol extract of the plant on gastrointestinal propulsion, in vitro bacterial growth and in vivo bacillary dysentery. Materials and Methods: Materials and Methods: Diarrhea was induced by oral administration of 12 × 10 8 Shigella dysenteriae type 1 (Sd1) cells. Diarrheic rats were treated for 5 days with 10, 20 or 40 mg/kg extract or 20 mg/kg norfloxacin. The faeces frequencies and the number of Sd1 were assessed and the death rate recorded. Results: Results: The aqueous ethanol extract of E. prostrata was not toxic. In vitro, the minimal inhibitory and minimal bactericidal concentrations of the extract were 3,500 and 12,000 µg/ml, respectively. In vivo, diarrhea went along with increase in faeces frequency (P < 0.01 by the 3 rd day), increase in the bacterial population to a maximum on the 2 nd day after infection (P < 0.01). The death rate in diarrheic control group was 100% by day 6. E. prostrata extracts (20 and 40 mg/kg), like norfloxacin, reduced the bacterial growth (P < 0.01), so that by the 6 th day Sd1 density was <100 and no death was recorded. There was a significant (P < 0.01) reduction in faeces frequencies. The extract exhibited notable (P < 0.01) inhibition of intestinal propulsion. Conclusion: Conclusion: The results suggest that E. prostrata possesses bactericidal and antidiarrheic properties and could be a therapeutic alternative for diarrheas of bacterial etiology.

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Section: Discussionmentioning

confidence: 99%

Activity of aqueous ethanol extract of Euphorbia prostrata ait on Shigella dysenteriae type 1-induced diarrhea in rats

et al. 2007

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“…Certains germes saprophytes peuvent cependant être à l'origine de maladie digestive, soit s'ils ont pu pénétrer la muqueuse digestive, soit si le terrain fragilisé (par exemple dans le cas d'une immunodépression) permet leur expression. Ces germes sont alors considérés comme des germes opportunistes [3].…”

Section: Pathogènes Responsables Des Diarrhées Aiguës Bactériennes Etunclassified

“…De nombreux germes et bactéries responsables de diarrhées tropicales ont été identifiés [3][4][5][6]. Le traitement reposait sur le cotrimoxazole, l'ampicilline, le chloramphénicol mais les résistances sont maintenant fréquentes, faisant préférer actuellement les quinolones (résistances en augmentation) ou les céphalosporines de 3 e génération.…”

Section: Bactéries Et Germes Responsables Des Diarrhées Tropicalesunclassified

Diarrhées aiguës infectieuses

Truchis

Truchis²

2007

La Presse Médicale

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Acute infectious diarrhea has various causes: bacterial diarrhea with invasive or toxigenic mechanisms, especially frequent in hot regions and in travelers; viral diarrheas, frequent and cosmopolitan in children but also adults; and parasitic diarrhea, less frequent, and generally in subtropical areas. The major concerns involve the risk of complications, essentially dehydration and malnutrition, especially in vulnerable patients: young children, the elderly, and patients with immunosuppression, for whom rehydration is urgent. Diagnosis of diarrhea requires clinical assessment and history: underlying illnesses, severity of symptoms, presence and extent of dehydration and other clinical symptoms, travel history, known outbreaks, and pathogenic mechanism (invasive or toxigenic). Initial therapy should always include oral or parenteral rehydration; antimotility agents are generally not indicated; specific antibiotic treatment is not systematically indicated, except for invasive or dysenteric diarrhea and in immunosuppressed patients.

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Cyclospora sp. et Isospora belli

Miégeville¹

2006

EMC - Biologie Médicale

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Diarrhées aiguës infectieuses

Cited by 3 publications

References 19 publications

Activity of aqueous ethanol extract of Euphorbia prostrata ait on Shigella dysenteriae type 1-induced diarrhea in rats

Activity of aqueous ethanol extract of Euphorbia prostrata ait on Shigella dysenteriae type 1-induced diarrhea in rats

Diarrhées aiguës infectieuses

Cyclospora sp. et Isospora belli

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