2020
DOI: 10.1016/j.bioorg.2020.104017
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Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity

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Cited by 13 publications
(5 citation statements)
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“…As such, several VDAs have been tested in combination with additional therapies, including radiotherapy [ 22 , 23 ], antiangiogenic agents (such as bevacizumab) [ 24 ] and, recently, immunotherapy [ 25 ]. There is a current resurgence of interest in VDAs, and frequent reports describe novel agents, many based on the combretastatin motif [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], including benzosuberenes [ 37 , 38 , 39 , 40 ]. 2-Methoxy-5-(3′,4′,5′-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-ol (also referred to as KGP18; Figure 1 ) has structural similarities to the combretastatins (e.g., the trimethoxyaryl group) and was found to exhibit exceptional biological properties, suggesting it would provide effective tumor vascular disruption.…”
Section: Introductionmentioning
confidence: 99%
“…As such, several VDAs have been tested in combination with additional therapies, including radiotherapy [ 22 , 23 ], antiangiogenic agents (such as bevacizumab) [ 24 ] and, recently, immunotherapy [ 25 ]. There is a current resurgence of interest in VDAs, and frequent reports describe novel agents, many based on the combretastatin motif [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], including benzosuberenes [ 37 , 38 , 39 , 40 ]. 2-Methoxy-5-(3′,4′,5′-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-ol (also referred to as KGP18; Figure 1 ) has structural similarities to the combretastatins (e.g., the trimethoxyaryl group) and was found to exhibit exceptional biological properties, suggesting it would provide effective tumor vascular disruption.…”
Section: Introductionmentioning
confidence: 99%
“…These compounds were found to interfere with the microtubule-tubulin equilibrium in cancer cells and were demonstrated to retain anti-proliferative activity on a panel of cancer cell lines. Compounds targeting tubulin are of great interest for the treatment of cancer cells (45)(46)(47)(48).…”
Section: Synergistic Effects Of the Combined Treatment Of U251 And T98g Glioma Cells With An Anti-tubulin Tetrahydrothieno[23-c]pyridine mentioning
confidence: 99%
“…17 A property that makes analogs of CA-4 attractive for further development of more appropriate anticancer molecules which could be utilized in clinical use to overcome the drawbacks of conventional anticancer regimens, especially development of drug resistance. 18–20…”
Section: Introductionmentioning
confidence: 99%
“…17 A property that makes analogs of CA-4 attractive for further development of more appropriate anticancer molecules which could be utilized in clinical use to overcome the drawbacks of conventional anticancer regimens, especially development of drug resistance. [18][19][20] Acrylate moiety is a common structural scaffold in the structure of numerous natural and synthetic small compounds displaying versatile biological interests. 21,22 It has been reported to exhibit diverse biomedical activities, including anticancer activity.…”
Section: Introductionmentioning
confidence: 99%