Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease

Abstract

Two fluorescent switchable diarylethene derivatives which exhibit high affinity for amyloid-β aggregates with the increase of fluorescence intensity were reported. Moreover, the probes show excellent photochromic and anti-photobleaching properties both in vitro and in vivo.

Fluorescence Detection and Dissociation of Amyloid‐β Species for the Treatment of Alzheimer's Disease

“…[49] The fluorescence emission and binding affinities can be adjusted effectively by changing substituent groups on the naphthalene ring. [50] Both T1 and T2 can specifically bind to the hydrophobic cavity of Aβ aggregates, and the fluorescence intensity significantly increased after binding, accompanied with a blueshift about 30 nm. In order to improve solubility and photostability of Aβ imaging probes, Yi and coworkers combined the Aβ-aggregate targeting probe ANCA with arylethene (DAE) to synthesize fluorescent probes T1 and T2 (Figure 4) with photo-switching function.…”

A multi-state fluorescence switch based on a new photochromic diarylethene with a di-(ethyl-1,8-naphthalimidyl)amine unit

“…The molecules with both photochromic and fluorescent properties have attracted increasing interest because of their potential applications as molecular switches and biological markers [4][5][6][7][8][9][10]. However, most diarylethene molecules are not appreciably fluorescent.…”

Light‐Controlled Release and Uptake of Zinc Ions in Solution by a Photochromic Terthiazole‐Based Ligand

“…Owing to their good photochromic features, especially in terms of thermal stability and fatigue-resistance, diarylethenes have emerged over the last few decades as av ery popular class of opticalm olecular switches fort he design of various photo-responsive systems. [1][2][3][4][5][6][7][8][9][10][11][12][13] In principle, it is possible to photo-modulate any structure-dependent property of as ystem by exploiting the reversible structural changes of an appropriate diarylethene-baseds witch. In this regard, associationo f photochromic diarylethenes with metal ions is appealing as it providesaconvenient way to photo-switch properties and functions, which are not always readilya ccessible within pure organic systems.…”