Diastereodivergent additions of aluminum and magnesium reagents to [(S)S]-3,6-dimethoxy-2-(p-tolylsulfinyl)-benzaldehyde

Stereodivergent routes in organic synthesis: marine natural products, lactones, other natural products, heterocycles and unnatural compounds

“…Diastereodivergent routes to bicyclo[3.1.0]hexanes.Enantiodivergent routes to 2,5-dimethoxyphenyl methyl carbinols have been reported by Carreño, Urbano and co-workers117 starting from [(S)S]-3,6dimethhoxy-2-(p-tolylsulfonyl)benzaldehyde. The addition of MeMgBr gave the (S)-alcohol in 98% de, while Me3Al afforded the (R)-alcohol also in 98% de (Scheme 74).…”