Diastereoselective addition of an NiII complex of a Schiff base of glycine with (S)-2-[N-(N-benzylprolyl)amino]benzophenone to the C=C bond of ethyl α-bromoacrylate

4-[18F]Fluoroglutamic Acid (BAY 85-8050), a New Amino Acid Radiotracer for PET Imaging of Tumors: Synthesis and in Vitro Characterization

“…6 Besides glucose, tumors also show an enhanced demand for certain amino acids. Therefore, 18 F-labeled amino acids could be interesting alternatives for tumor imaging. For example, [ 18 F]fluoroethyl tyrosine ([ 18 F]FET, 2; see Chart 1) is currently evaluated for the in vivo targeting of brain tumors.…”

“…Structures of 1 ([ In fact, the tumor/nontumor tissue ratios for 2 are by far lower than for 1 except within the brain. 8 Therefore, a highly accumulating tumor specific 18 F-labeled amino acid tracer is of outmost interest.…”

“…After deamidation of glutamine, glutamate is further transaminated to 2-oxoglutarate, which is directly channeled into the truncated TCA cycle, where it is further metabolized in several consecutive reactions to provide energy and building blocks (Figure 1). Therefore, 18 Flabeled derivatives of glutamine/glutamate are of particular interest.…”

Chiral nickel(ii) complexes in the preparation of11C- and18F-labelled enantiomerically pure α-amino acids

“…32 An original one-pot formation of a cyclic core of a quaternary amino acid containing two stereogenic centres was also developed. 33,34 The most common application of nickel complexes as chiral amino acids synthons for preparation of analogues of aromatic aamino acids or a-amino acids with aliphatic side chains consists of several standard steps (Scheme 1):…”

Functionalization of Indole and Pyrrole Cores via Michael-Type Additions

“…N-Michael addition of indole to achiral Ni(II) complex 278 led to the synthesis of racemic α-amino acid 280 [202]. The first of the two-step reactions is realized in the presence of NaH in acetonitrile.…”