Diastereoselective and one-pot synthesis of trans-isoquinolonic acids via three-component condensation of homophthalic anhydride, aldehydes, and ammonium acetate catalyzed by aspartic acid

Synthesis and characterization of copper(II) Schiff base complex supported on Fe3O4 magnetic nanoparticles: a recyclable catalyst for the one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones

“…In connection with our ongoing work on multi‐component condensations, we now report a facile, rapid and one‐pot two‐component combination for the preparation of 2,3‐dihydroquinazolin‐4(1H)‐one derivatives in the presence of Schiff base complex of Cu(II) immobilized on Fe 3 O 4 as a heterogeneous, non‐toxic, reusable, inexpensive and easily available catalyst (Scheme ).…”

Mechanistic Investigation of Castagnoli–Cushman Multicomponent Reactions Leading to a Three-Component Synthesis of Dihydroisoquinolones

“…The CCR also forms the basis of a three-component reaction (3CR) of homophthalic anhydride, amines, and aldehydes with Lewis acid catalysts and additives. − In one case, a diacid is used as an anhydride precursor . Similar zwitterionic intermediates were proposed for the 3CR of homophthalic anhydride with amines and aldehydes, wherein the amine attacks homophthalic anhydride to form amide-acid 11 , followed by condensation with aldehyde 9 and successive Mannich addition (Figure A) .…”

Palladium supported on modified magnetic nanoparticles: a phosphine‐free and heterogeneous catalyst for Suzuki and Stille reactions

“…As a part of our continuing interest in the development of efficient and new heterogeneous catalysts for organic synthesis, herein we report a recoverable and efficient MNP‐supported Pd (Fe 3 O 4 /SiO 2 ‐PAP‐Pd) complex, which exhibits a high catalytic activity in the Suzuki and Stille cross‐coupling reactions. In addition, the catalyst can be easily recovered from the reaction mixture by simple filtration and reused at least five times without significant loss of its catalytic activity.…”