Diastereoselective syntheses of pyrazolyl isoxazolidines via 1,3-dipolar cycloaddition

The synthesis and photophysical studies of quinoxaline and pyridopyrazine derivatives

“…As part of our ongoing research in the development of novel synthetic routes to the synthesis of biologically active heterocyclic compounds and use of green chemistry techniques in organic synthesis [23,24], herein we disclose a simple and convenient method for the synthesis of quinoxaline derivatives from cinnamils in water under reflux/microwave irradiation conditions (Scheme 1) and their photophysical properties were evaluated.…”

Antibacterial Activity, Quantitative Structure–Activity Relationship and Diastereoselective Synthesis of Isoxazolidine Derivatives Via 1,3‐Dipolar Cycloaddition of d‐glucose Derived Nitrone with Olefin

“…The oxygen of the 1,3-dipole 1a attacks the electron-deficient b-carbon of the olefin 2b to form the corresponding single endo-diastereoisomer 3b (Table 1, entry 2, determined by crude 1 H NMR spectra) in good yield. The endo stereochemistry of the cycloadduct was assigned based on the coupling constant values and comparison with earlier reports (32,47). We have employed olefins with electron-withdrawing substitution in our studies and obtained the endo isomer.…”

“…In continuation of our interest in the diastereoselective 1,3-dipolar cycloaddition of nitrones (32), we herein disclose our findings on the chiral 1,3-dipolar cycloaddition of sugar derived nitrones. The required IR measurements were performed as KBr pellets for solids using Perkin Elmer Spectrum RXI FT-IR.…”

An ionic liquid {[secbmim]+ Br¯} as a “dual reagent catalyst” for the multicomponent synthesis of (quinolinyl- and isoquinolinyl- amino) alkylnaphthols, their bis- analogs and a facile route to naphthoxazines

“…18 This moiety has generated great interest as anti-psychotic agents and as probable effectors for dopamine and serotonin receptors. 19 Moreover, benzo-1,3-oxazines are biologically active as anti-malarial, 20 anti-anginal, 21 anti-hypertensive 22 and potent anti-rheumatic 23 agents. Keeping in mind such high importance of these 1,3-oxazines, a number of naphtho-1, 3-oxazines were synthesized and the results are depicted in Table 4.…”