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Pyrazole derivatives R 0180Design, Synthesis and anti-Microbial Activity of 1H-Pyrazole Carboxylates. -Dinitrophenyl hydrazones of β-ketoesters, (I), upon treatment with the Vilsmeier reagent yield pyrazole carboxylate related microbicides (III). Following the same procedure, the formyl pyrazole carboxylate (V) is obtained. The pyrazoles are active towards both plant pathogenic fungal growth inhibition and bacterial inhibition. Among the eight compounds tested, (V) significantly inhibits most of the bacterial growth and exhibits highly significant anti-fungal activity against different fungi. The first X-ray crystal structure in the family of microbicidal pyrazole-4-carboxylates is presented, cf. (IIIg). -(SRIDHAR, R.; PERUMAL*, P. T.; ETTI, S.; SHANMU-GAM, G.; PONNUSWAMY, M. N.; PRABAVATHY, V. R.; MATHIVANAN, N.; Bioorg. Med.

The title compound, C19H18O8 [systematic name: 5‐hydroxy‐2‐(3‐hydroxy‐4,5‐di­methoxy­phenyl)‐3,7‐di­methoxy­chromen‐4‐one], an extract from Premna tomentosa willd, is used in the Siddha system of medicine practiced in South India. The dihedral angle between the mean planes through the benzo­pyran moiety and benzene ring is 38.60 (7)°. A strong O—H·O intramolecular hydrogen bond is observed in the molecular structure. O—H·O and C—H·O hydrogen bonds and π–π interactions stabilize the mol­ecules in the crystal packing.

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