Planar-chiral
ferrocenes are widely applied in catalytic asymmetric
transformations in scientific research as well as in industry. A plethora
of different methodologies have been developed to access these molecules
with a high degree of regio- and stereoselectivity. The aim of this
contribution is to give a comprehensive overview of this topic. The
synthesis of 1,2- and 1,3-substituted ferrocenes by electrophilic
aromatic substitution, ortho-directed metalation, kinetic resolution,
and desymmetrization is discussed. Advantages and disadvantages are
highlighted.