Diastolic Dysfunction

Jeong, Euy Myoung; Dudley, Samuel C.

doi:10.1253/circj.cj-15-0064

Cited by 94 publications

(92 citation statements)

References 65 publications

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“…Increased oxidative stress and cardiac oxidation has also been associated with diastolic dysfunction[47]. The toxic effects of ROS can be prevented in part by the antioxidant enzyme system including GSH-Px, SOD and catalase[55].…”

Section: Discussionmentioning

confidence: 99%

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

et al. 2017

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BackgroundMyocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown.Methods and resultsTo determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively.ConclusionOur findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling.

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Section: Discussionmentioning

confidence: 99%

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

et al. 2017

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“…Over the past 2 decades, the syndrome of heart failure with preserved ejection fraction (HFpEF) received a lot of attention 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19. However, little therapeutic progress was made 20, 21, 22, 23, 24, 25, 26, 27.…”

Section: Introductionmentioning

confidence: 99%

“…As a whole, HFpEF has been extensively reviewed 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19. The present review focuses on 4 commonly encountered clinical phenotypes of HFpEF and their comorbid conditions (Figure).…”

Section: Introductionmentioning

confidence: 99%

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

Samson

Jaiswal

Ennezat

et al. 2016

JAHA

109

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“…The isovolumic relaxation time constant (τ) is used to characterize the active phase of cardiac relaxation using the exponential intra-ventricular pressure decline during early diastole. This value is measured clinically using indirect methods that correlate with the pressure derived relaxation time constant [9]. This index has been shown to be inversely related to diastolic cardiac function and represents the active energy consumption portion of ventricular relaxation [10].…”

Section: Introductionmentioning

confidence: 99%

“…This index has been shown to be inversely related to diastolic cardiac function and represents the active energy consumption portion of ventricular relaxation [10]. It has been shown that this index is useful in the diagnosis or theraputic follow-up of patients with diastolic heart failure or Heart Failure with preserved Ejection Fraction (HFpEF) [9], [11] . The systolic/diastolic stiffness ratio is another potential functional index that provides a ratio-metric measure of the contractile and compliance states of the myocardium.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart

Vejdani‐Jahromi

Nagle

Yang

et al. 2016

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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In the past decade, there has been an increased interest in characterizing cardiac tissue mechanics utilizing newly developed ultrasound-based elastography techniques. These methods excite the tissue mechanically and track the response. Two frequently used methods, acoustic radiation force impulse and shear wave elasticity imaging (ARFI and SWEI), have been considered qualitative and quantitative techniques providing relative and absolute measures of tissue stiffness respectively. Depending on imaging conditions, it is desirable to identify indices of cardiac function that could be measured by ARFI and SWEI and to characterize the relationship between the measures. In this study, we have compared two indices (i.e. relaxation time constant used for diastolic dysfunction assessment and systolic/diastolic stiffness ratio) measured nearly simultaneously by M-mode ARFI and SWEI techniques. We additionally correlated ARFI-measured inverse displacements with SWEI measured values of the shear modulus of stiffness. For the eight animals studied, the average relaxation time constant ( ) measured by ARFI and SWEI were (69±18 ms, R2=0.96) and (65±19 ms, R2=0.99), (ARFI-SWEI inter-rater agreement = 0.90). Average systolic/diastolic stiffness ratio for ARFI, and SWEI measurements were 6.01±1.37 and 7.12±3.24 respectively (agreement=0.70). Shear modulus of stiffness (SWEI) was linearly related to inverse displacement values (ARFI) with a 95% CI for the slope of 0.010–0.011 (1/μm)/(kPa) (R2=0.73). In conclusion, the relaxation time constant and the systolic/diastolic stiffness ratio were calculated with good agreement between the ARFI and SWEI derived measurements. ARFI relative and SWEI absolute stiffness measurements were linearly related with varying slopes based on imaging conditions and subject tissue properties.

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Diastolic Dysfunction

Cited by 94 publications

References 65 publications

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart

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