Diastolic dysfunction precedes myocardial hypertrophy in the development of hypertension

Aeschbacher, Beat C.

doi:10.1016/s0895-7061(00)01245-0

Cited by 135 publications

(94 citation statements)

References 45 publications

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“…Indeed, in previous studies mildly hypertensive patients demonstrated LV diastolic dysfunction without LV hypertrophy. 34,35 In our study, the correlation was closer for the visit-to-visit SBP variability parameters than for mean SBP. These results indicate that visit-to-visit variability in SBP over a 1-year period may be a marker of LV diastolic dysfunction in treated hypertensive patients.…”

Section: Discussionsupporting

confidence: 44%

Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients

et al. 2011

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Although visit-to-visit variability in systolic blood pressure (SBP) has recently been demonstrated to be a strong predictor of stroke, there are no data about relationships between SBP variability and cardiac damage in hypertensive patients. We compared relationships between visit-to-visit variability in SBP and left ventricular (LV) diastolic dysfunction with the relationships between the mean SBP value and cardiac parameters in treated patients. Forty treated hypertensive patients (69±9 years of age) had their blood pressure measured at outpatient clinics every 1 or 2 months over a 1-year period. The standard deviation (s.d.) of SBP and the difference between the maximum and minimum SBPs during this year were calculated to assess visit-to-visit variability. The mean SBP during the year was also calculated. LV diastolic function was assessed by the ratio (E/A) of early (E) and late (A) diastolic transmitral flows, early diastolic mitral annular velocity (e¢) and the ratio (E/e¢) of E to e¢ using Doppler echocardiography. E/A only correlated with the s.d. of SBP (r¼À0.327, P¼0.040), whereas e¢ correlated with s.d. of SBP (r¼À0.496, P¼0.001) and maximum-minimum SBP difference (r¼À0.490, P¼0.001). E/e¢ correlated with s.d. of SBP (r¼0.384, P¼0.014), maximum-minimum SBP difference (r¼0.410, P¼0.009), and the mean value of SBP (r¼0.349, P¼0.028). Multiple regression analysis demonstrated only the maximum-minimum SBP difference independently associated with E/e¢ (b¼0.410, P¼0.009). Thus, the visit-to-visit variability of SBP showed better correlation with LV diastolic dysfunction than mean values of SBP. High visit-to-visit variability of SBP was associated with LV diastolic dysfunction and may constitute a high risk for diastolic heart failure in hypertensive patients.

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Section: Discussionsupporting

confidence: 44%

Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients

et al. 2011

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“…These observations are also compatible with our interpretation. On the other hand, normotensive subjects with left ventricular hypertrophy or diastolic dysfunction are at increased risk from the future development of hypertension (25,26). Thus, the contribution of left ventricular hypertrophy or diastolic dysfunction to the mild increase in baseline BNP levels in subjects who developed hypertension during the follow-up is also possible, although we cannot verify the possibility because the participants did not undergo echocardiography at baseline.…”

Section: Discussionmentioning

confidence: 93%

Does B-Type Natriuretic Peptide Predict the New Onset of Hypertension?

et al. 2008

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Increased B-type natriuretic peptide (BNP) expression precedes the development of hypertension in spontaneously hypertensive rats. We therefore tested the hypothesis that elevated plasma BNP levels predict the onset of hypertension in normotensive subjects. Japanese normotensive participants who were at our hospital for a yearly physical check-up (mean age 52.7 years, 35.9% women, n =5,026) were enrolled in the study. Blood pressure and BNP were measured at baseline and subjects were followed up for 5 years (median 1,114 d), with the endpoint being the development of hypertension. We evaluated the relationship between plasma BNP levels at baseline and the incidence of hypertension during the follow-up period.

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“…There is a substantial body of evidence that abnormalities of LV diastolic properties may occur in the presence of normal ejection fraction, 3,4 often yielding the conclusion that abnormalities in LV diastolic function may precede or be independent of systolic dysfunction. However, studies that use midwall fractional shorting instead of EF as an index of systolic function found depressed LV systolic performance occuring coincidently with impaired diastolic function.…”

Section: Discussionmentioning

confidence: 99%

“…The prolonged mitral annulus myocardial IVCT 0 found in NLVH and LVH group of present study may represent an early marker of LV systolic dysfunction, and this means our patients were not in early stage of hypertensive heart disease. 3 Tei index was recently proposed as a potentially useful predictor of global myocardial performance, and it was defined as the sum of IVCT and IVRT divided by the ejection time. Tei index was reported to be simple, reproducible and independent of HR and blood pressure.…”

Section: Discussionmentioning

confidence: 99%

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Effect of cilnidipine on left ventricular function in hypertensive patients as assessed by tissue Doppler Tei index

Zhang

et al. 2006

J Hum Hypertens

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Diastolic dysfunction precedes myocardial hypertrophy in the development of hypertension

Abstract: Background: Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension, but longitudinal studies are missing.

Cited by 135 publications

References 45 publications

Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients

Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients

Does B-Type Natriuretic Peptide Predict the New Onset of Hypertension?

Effect of cilnidipine on left ventricular function in hypertensive patients as assessed by tissue Doppler Tei index

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