Diastolic function and insulin resistance in essential hypertension

Žemva, Aleš; Pernat, Andreja Marn; Jelenc, Marjetka; Žemva, Žarka

doi:10.1016/s0167-5273(98)00245-9

Cited by 7 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported that the existence of hyperinsulinemia or insulin resistance is related to LV diastolic dysfunction in nondiabetic hypertensives (27,(30)(31)(32)(33)(34)(35). In addition, some of these studies reported that the relation between the two was independent of LVMI (31)(32)(33). Studies on the association between insulin and LV mass in humans have yielded conflicting results (23,27,31,(33)(34)(35)(36)(37)(38)(39)(40), but recent studies have demonstrated that neither plasma insulin concentration nor insulin sensitivity is an independent determinant of LVMI in nondiabetic subjects (38,39).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fasting Plasma Glucose Is an Independent Determinant of Left Ventricular Diastolic Dysfunction in Nondiabetic Patients with Treated Essential Hypertension.

et al. 2002

View full text Add to dashboard Cite

with heart failure (5, 6). Therefore, early detection and prevention of such cardiac dysfunction is an important goal in the management of hypertensive patients. In a study by Phillips et al. (7), however diastolic abnormalities of ventricular function persisted despite effective control of blood pressure in treated hypertensive patients, and these abnormalities were independent of LV hypertrophy, suggesting that some factor other than blood pressure or cardiac hypertrophy may affect diastolic function in treated hypertension.Both diabetes mellitus and hypertension are known to deteriorate cardiac diastolic performance, and the combination of these two diseases induces more severe abnormalities in

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fasting Plasma Glucose Is an Independent Determinant of Left Ventricular Diastolic Dysfunction in Nondiabetic Patients with Treated Essential Hypertension.

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Patients with insulin resistance have been reported to develop left ventricular hypertrophy and diastolic dysfunction because of their reduced ability to adapt to hypertensive stress 41,42) . Another study showed that systemic insulin resistance has a high prevalence among patients with idiopathic dilated cardiomyopathy 43) .…”

Section: Heart Failure and Adipose Tissue Inflammationmentioning

confidence: 99%

The pathological role of adipose tissue aging in the progression of systemic insulin resistance

Yoshida

Shimizu

Minamino

2015

Inflammation and Regeneration

View full text Add to dashboard Cite

The prevalence of obesity, diabetes and heart failure increases with aging, and there is evidence that these age-related disorders share common pathologic features such as chronic low-grade inflammation and systemic metabolic dysfunction. Cellular senescence was initially discovered by in vitro studies, but it is now widely accepted that this process also occurs in vivo with aging. The p53 signaling pathway has a central role in the regulation of cellular senescence, and several lines of evidence indicate that cellular senescence has a causative role in the progression of agerelated disorders. In obesity, chronic low-grade inflammation of visceral fat is characterized by production of pro-inflammatory cytokines and infiltration of immune cells, which induces systemic insulin resistance (hyperinsulinemia) that leads to the development of diabetes. Recently, p53-induced cellular senescence was reported to have a critical role in this process. In murine heart failure models, cellular senescence due to activation of p53 not only contributes to adipose tissue inflammation and systemic insulin resistance, but also to the progression of heart failure. This review outlines the pathological role of cellular senescence occurring in white adipose tissue in the development of obesity, diabetes, and heart failure.Rec.5/19/2015, Acc.6/15/2015, pp178-184

show abstract

“…On the other hand, glomerular dysfunction, intrarenal arteriosclerosis, interstitial fibrosis, and interstitial edema are related to the alteration in intrarenal hemodynamics in diabetic patients (32)(33)(34)(35)(36). Furthermore, many studies have reported that hyperinsulinemia and insulin resistance may contribute to both LV diastolic dysfunction (37)(38)(39) and glomerular hyperten- , diastolic-to-systolic ratio; RI, resistance index; A/E, peak velocity ratio of the atrial filling wave-to-early diastolic filling wave; DcT, deceleration time of the E wave; GT, glucose tolerance. sion and hyperfiltration (40)(41)(42).…”

Section: Fig 1 Correlation Between Renal Doppler Parameters (D/s Anmentioning

confidence: 99%

Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

et al. 2003

View full text Add to dashboard Cite

The heart and kidneys are important target organs in hypertension. Early signs of hypertensive target organ Abnormalities in left ventricular (LV) diastolic filling have been described in patients with hypertension, even in the absence of left ventricular hypertrophy (7-9). Moreover, impaired LV diastolic relaxation is a prognostic indicator of cardiovascular risk (10). An increased intrarenal resistance index (RI) evaluated by renal Doppler ultrasonography has also been reported in patients with essential hypertension (11,12). Assessment of intrarenal vascular resistance is useful in determining the degree of intrarenal damage. High levels of RI are associated with subclinical end-organ damage-namely microalbuminuria, LV hypertrophy, and carotid atherosclerosis-in hypertensive patients (13,14). In addition, an RI value of ≥ 0.8 is a strong and independent

show abstract

Diastolic function and insulin resistance in essential hypertension

Cited by 7 publications

References 23 publications

Fasting Plasma Glucose Is an Independent Determinant of Left Ventricular Diastolic Dysfunction in Nondiabetic Patients with Treated Essential Hypertension.

Fasting Plasma Glucose Is an Independent Determinant of Left Ventricular Diastolic Dysfunction in Nondiabetic Patients with Treated Essential Hypertension.

The pathological role of adipose tissue aging in the progression of systemic insulin resistance

Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

Contact Info

Product

Resources

About