Diastolic left ventricular dysfunction in ankylosing spondylitis—A systematic review and meta-analysis

Insights into cardiac involvement in ankylosing spondylitis from cardiovascular magnetic resonance

“…One of the most important known cytokines in the development of inflammation-driven fibrosis is transforming growth factor β, which has been shown to exert synergistic effects on the induction of collagen gene expression and inhibition of the collagen degradation system 28. Furthermore, the high prevalence of LV diastolic dysfunction in our study population, and in patients with ankylosing spondylitis in general, also supports the presence of diffuse interstitial fibrosis 4. It is currently believed that myocardial fibrosis can contribute to high LV diastolic stiffness, which can ultimately lead to impairment of ventricular relaxation and filling 29.…”

“…Epidemiological studies have described a higher prevalence of cardiovascular disease in patients with ankylosing spondylitis compared with the general population, especially congestive heart failure (prevalence ratio of 1.8) and ischaemic heart disease (prevalence ratio of approximately 1.3) 3. In addition, several echocardiography studies have shown an increased prevalence of diastolic left ventricular (LV) dysfunction and aortic valve regurgitation in ankylosing spondylitis 4 5. The exact pathophysiological mechanism behind LV diastolic dysfunction in ankylosing spondylitis is not fully understood.…”

Echocardiography in the Assessment of Patients with Rheumatologic Diseases

“…Diastolic dysfunction is reported in 9-45 % of patients with AS [19]. In the majority of cases, it appears to be grade I (abnormal relaxation pattern) and is associated with smoking, high body mass index and hypertension [65,66].…”

“…-Present in 9-45 % of the patients [19]. -Increased risk of CAD with a reported hazard ratio of 1.41 [20].…”

The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis

“…Recently, we performed a review that suggested a higher prevalence of diastolic LV dysfunction in AS patients, an important precursor to chronic HF that may contribute to the enhanced morbidity and mortality in AS. 8 Considering this, in this study we investigated the precise magnitude of LV dysfunction, particularly diastolic LF dysfunction, in AS patients and we examined the effect of tumor necrosis factor alpha (TNF-α) blocking therapy on LV function during a treatment period of 1 year.…”