1978
DOI: 10.1002/j.1552-4604.1978.tb02448.x
|View full text |Cite
|
Sign up to set email alerts
|

Diazepam and Lorazepam for Intravenous Surgical Premedication

Abstract: Diazepam, 10 and 20 mg, and 2 and 4 mg lorazepam were studied as intravenous surgical premedicants in 120 patients. Relief of anxiety, sedation, patient acceptance, lack of recall, and side effects were the variables evaluated. Both diazepam and lorazepam proved to be excellent surgical premedicants. The basic difference between the two drugs is temporal. Both medications produce similar relief of anxiety, sedation, patient acceptance, and lack of recall. The clinical effects of intravenous diazepam peaks in 2… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

1984
1984
2009
2009

Publication Types

Select...
4
3

Relationship

0
7

Authors

Journals

citations
Cited by 22 publications
(2 citation statements)
references
References 9 publications
0
2
0
Order By: Relevance
“…No retrograde amnesic effect was obtained, but the marked anterograde amnesia associated with flunitrazepam in children seems to equal that observed in adult (Dundee et al, 1976;Korttila and Linnoila, 1976;George and Dundee, 1977) and elderly (Hovi-Viander et al, 1982) patients. However, this effect is not always desirable since the loss of self-control may be alarming for some patients (Conner et al, 1978). Consequently, these problems should be discussed with patients, especially with the more grown-up children, during the preoperative visit (Kanto and Klotz, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…No retrograde amnesic effect was obtained, but the marked anterograde amnesia associated with flunitrazepam in children seems to equal that observed in adult (Dundee et al, 1976;Korttila and Linnoila, 1976;George and Dundee, 1977) and elderly (Hovi-Viander et al, 1982) patients. However, this effect is not always desirable since the loss of self-control may be alarming for some patients (Conner et al, 1978). Consequently, these problems should be discussed with patients, especially with the more grown-up children, during the preoperative visit (Kanto and Klotz, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…Systemic administration of diazepam may cause irritation and phlebitis at the injection site. After intravenous administration axiolysis and sedation are achieved faster with diazepam than lorazepam [24]. Even if lorazepam has a shorter half-life and no active metabolites compared to diazepam, its clinical effect may be longer because of its higher receptor affinity [25,26].…”
Section: Sedative-hypnotics and Tranquilizersmentioning
confidence: 99%