1984
DOI: 10.1093/bja/56.8.899
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Flunitrazepam as an Induction Agent in Children

Abstract: Flunitrazepam was studied as an induction agent in paediatric patients. The onset of action was slow and its efficacy uncertain following single doses of 0.03 mg kg-1(n = 4), or 0.04 mg kg-1 (n = 6) i.v. Long-lasting sedative effects were observed following operation. A strong anterograde but not retrograde amnesic effect was obtained, and a possible analgesic sparing property. Flunitrazepam has a faster and more extensive tissue distribution and a more rapid elimination (half-life about 12 h) in children than… Show more

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Cited by 6 publications
(5 citation statements)
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“…In the present study, however, an influence of postnatal age but not of gestational age was shown on clearance and volume of distribution. These results are consistent with the data on the development of the cytochrome P450 in neonates and infants 4 . The clearance values were lower than those reported in children from 3 to 6 years old (0.5 ± 0.1 L · h −1 · kg −1 ).…”
Section: Discussionsupporting
confidence: 92%
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“…In the present study, however, an influence of postnatal age but not of gestational age was shown on clearance and volume of distribution. These results are consistent with the data on the development of the cytochrome P450 in neonates and infants 4 . The clearance values were lower than those reported in children from 3 to 6 years old (0.5 ± 0.1 L · h −1 · kg −1 ).…”
Section: Discussionsupporting
confidence: 92%
“…When compared with the published flunitrazepam pharmacokinetic parameters, the mean half‐life was close to the values reported in adults (20 to 36 hours, 11 25 ± 6 hours, 12 29 ± 11 hours, 3 22.9 ± 6.4 hours, 7 and 25 ± 11 hours 8 ) but longer than the values published in older children (11.8 ± 3.7 hours 4 and 3.98 ± 4.8 hours 9 ). The area under the curve normalized for a same dose was similar to that described in adults by Kanto et al 3 No influence of age on flunitrazepam pharmacokinetics was shown in previous studies that involved elderly poor‐risk patients 7 and healthy adult surgical patients 3 , 8 .…”
Section: Discussionsupporting
confidence: 78%
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“…The precise function of the exosomes in normal cell physiology and in pathogenesis of diseased phenotype is unclear. Accumulating knowledgebases of exosomes in cancer (54), neurological (55), metabolic and cardiac disease (56), immune function (57) and virus infections (58) is beginning to provide a strong rationale for intervention and therapy for diverse diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Flunitrazepam was more effective than midazolam in doses similar to those used clinically to produce i.v. sedation and anaesthesia [19][20][21]. Concentrations of metabolites (DOPAC and HVA) in striatal dialysates tended to decrease after flunitrazepam, but were not affected by i.v.…”
Section: Discussionmentioning
confidence: 99%