Diazinon acute exposure induces neutrophil extracellular traps in Nile tilapia (Oreochromis niloticus)

Abstract

Diazinon is an organophosphate insecticide commonly used worldwide to chemically control different organisms considered as pests. In the past years, diazinon has been described to have immunotoxic effects in several species. Nile tilapia is a teleost fish with an ecological and economic importance, which is also one of the fishes with the highest consumption around the world. The aim of this study was to evaluate the production of neutrophil extracellular traps (NETs) from fish Nile tilapia (Oreochromis niloticus) exposed to diazinon (0.97, 1.95, and 3.91 mg/L) for 6 and 24 h. The results obtained indicate that the exposure to diazinon per se increases NETs production. Therefore, these results could be involved in the understanding of the inflammatory process induced by exposure to pesticides.

Cadmium aggravates liver injury by activating ferroptosis and neutrophil extracellular traps formation in Nile tilapia (Oreochromis niloticus)

“…Fish neutrophils can also release NETs that function similarly to those in mammals and stimulate fish immune defenses. Until now, bacterial, 34 virus, 35 diazinon, 36 avermectin, 37 fluorine, 38 and mercury 39 have been shown to induce NET formation in fish through a variety of mechanisms. Furthermore, recent studies have shown that NET formation exacerbates liver injury in cases of ischemia/reperfusion or nonalcoholic steatohepatitis 40,41 .…”