Diazoxide attenuates indomethacin-induced small intestinal damage in the rat

Curcumin has bright prospects for the treatment of multiple sclerosis

“…While systemic distribution of curcumin tends to be low, Garcea et al [32] demonstrated that 3.6 g curcumin given to 12 patients with varying stages of colorectal cancer for 7 days resulted in pharmacologically efficacious levels of curcumin in both malignant colorectal tissue (7.7± 1.8 nmol/g) and normal colorectal tissue (12.7 ± 5.7 nmol/g), perhaps accounting for the anti-inflammatory benefits of curcumin observed in diseases of the gastrointestinal tract [33].…”

Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target

“…In addition, there are very few flavonoids which have been studied in vivo, to mechanistically establish the role of TNF for the management of NSAID induced gastroenteropathy despite of many flavonoids having the potential results for anti-TNF activities from in vitro and in vivo studies [47]. For instance, as far as we know, only curcumin has been studied for its preventative role in animal models of NSAID induced gastropathy and enteropathy [233][234][235][236][237]. Importantly, the ability of curcumin M A N U S C R I P T…”

“…18 to attenuate the GI damage has been attributed to its ability to decrease TNF levels [233][234][235][236][237]. However, flavonoids are generally available as dietary supplements and their purity, quality and stability is not always well established [238,239].…”

Evidence of K+ channel function in epithelial cell migration, proliferation, and repair

“…In fact, K ATP channel function has been quite extensively studied in several gastrointestinal models. The K ATP channel opener diazoxide has been shown to attenuate the damage and/or accelerate the restitution of indomethacin-and ethanol-induced intestinal and gastric injury in rats and mice (2,87,98,113,114,122,142), whereas K ATP channel inhibition worsened damage parameters. Moreover, the gastroprotective effect of different compounds, such as the steroid saponin hecogenin (122), the antidepressant drug citalopram (124), or prostaglandins (108), seems dependent on K ATP channel function.…”