Dibenzocyclooctadiene Lignans from Schisandra lancifolia and Their Anti-human Immunodeficiency Virus-1 Activities

Anti‐hepatitis C virus activity of 3‐hydroxy caruilignan C from Swietenia macrophylla stems

“…Lignan derivatives are common substances present in the roots, stems, bark, fruit and seeds of many plant species, which have been shown to exhibit a variety of biological activities, including anti‐tumor [23], anti‐oxidative [24], anti‐hepatitis [25] and anti‐virus [26]. Recent studies have demonstrated that lignan derivatives exerted inhibitory activity against several viruses including human immunodeficiency virus‐1 [27,28], hepatitis B virus [29] and Japanese encephalitis virus [30], although the detailed mechanisms of this anti‐viral activity are still debatable. In the present study, we clearly demonstrated that a phytochemical constituent of SMS, 3‐HCL‐C, which is a lignan derivate, is promisingly effective in its anti‐HCV activity at both protein and RNA levels (Fig.…”

Two new lignans from Gymnotheca chinensis Decne

“…The NMR spectra indicated that it had a dibenzocyclooctadiene skeleton (Bowden et al, 1981;Yang et al, 2010Yang et al, , 2013. The HMBC (Fig.…”

A New Dibenzocyclooctadiene Lignan from Stems of Schisandra lancifolia and its Bioactivities

“…Thus, the structure of 1 was established, as shown and given the trivial name of lanciphenol A. Since some dibenzocyclooctadiene lignans from Schisandra species are reported to possess anti HIV-1 activity and cytotoxicity for cancer cell lines 7,8 , These activities were tested for compound 1.…”

“…It is a climbing plant mainly distributed in Mainland of China 6 . In previous studies, some new dibenzocyclooctadiene lignans were isolated from the fruits of S. lancifolia from of Erlang Mountain area of Sichuan Province 7 . In our continuing efforts to identify bioactive natural products from the medicinal plants of the Schisandraceae, a chemical investigation on the stems of S. lancifolia from Lijiang Country, Yunnan Province was carried out.…”