“…Analysis of the chemical composition of Schisandra chinensis demonstrated that the biologically active compounds are dibenzocyclooctadiene lignans, which have revealed a wide variety of active effects including antihepatotoxic (Chiu et al, 2003;Ip et al, 2000;Hikino et al, 1984), antioxidant and detoxificant (Ip et al, 1995;Ip & Ko, 1996;Mak et al, 1997;Chiu et al, 2005), anticancer (Wu et al, 2004), and anti-amnestic activities (Kim et al, , 2006. Recently, dibenzocyclooctadiene lignans were reported to reverse cancer drug resistance by targeting P-glycoprotein (P-gp) (Pan et al, 2005(Pan et al, , 2006Wan et al 2006), multidrug resistance-associated protein 1 (MRP1) (Li et al, 2007;Sun et al, 2007), and enhancing apoptosis (Li et al, 2006). Schisandrin C, as one of the important active dibenzocyclooctadiene lignans of Schisandra chinensis (Figure 1), has been used as a liver protective drug (Kiso et al, 1985).…”