Dibenzylbutyrolactone lignans from Piper cubeba

Badheka, L. P.; Prabhu, Bharathi R.; Mulchandani, N. B.

doi:10.1016/s0031-9422(00)85506-5

Cited by 28 publications

(20 citation statements)

References 11 publications

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“…The known compounds were identified as nemerosin (1) (Feliciano et al, 1989), isoscutellarein-8-methyl ether (4) (Tomimori et al, 1982), oroxylin (5) (Buschi et al, 1991;Biekofsky et al, 1991), wogonin (6) (Harrison et al, 1994;Joshi et al, 1983), eugenin (7) (Ali et al, 1990;Tsui and Brown, 1996), saikochromone A (8) (Kobayashi et al, 1990), kaerophyllin (9) (Mikaya et al, 1981), isokaerophyllin (10) (Gonzalez et al, 1990), (À)-yatein (11) (Badheka et al, 1986), chinensinaphthol (12) (Harrowven, 1993;Iwasaki et al, 1995) and 1,2,3,7-tetramethoxyxanthone (13) (Ikeya et al, 1991;Ito et al, 1977), by comparison of spectroscopic data in the literature and/or authentic compounds. Among these, compounds, 4-12 are reported for the first time from this plant.…”

Section: Resultsmentioning

confidence: 99%

Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium

et al. 2003

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Section: Resultsmentioning

confidence: 99%

Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium

et al. 2003

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“…Dimethylthujaplicatin methyl ether has already been found in Piper cubeba where M + is m/z = 416 and the base peak at m/z = 181 corresponds to the trimethoxyphenyl moiety. Fragments at m/z = 238 and 265 prove that the trimethoxyphenyl moiety is adjacent to the keto function of the lactone ring moiety [15].…”

Section: Resultsmentioning

confidence: 99%

A Phytochemical Study of Lignans in Whole Plants and Cell Suspension Cultures ofAnthriscus sylvestris

Koulman¹,

Kubbinga²,

Batterman³

et al. 2003

Planta med

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In the roots of Anthriscus sylvestris 12 different lignans were detected. Arctigenin, dimethylmatairesinol, dimethylthujaplicatin, podophyllotoxin, 7-hydroxyyatein and 7-hydroxyanhydropodorhizol have not been previously reported to be present in A. sylvestris. In the cell suspension cultures, which were initiated for this study, trace amounts of deoxypodophyllotoxin could be detected. With these cell suspension cultures we carried out feeding experiments using deoxypodophyllotoxin, yatein and, anhydropodorhizol. Yatein had a toxic effect on the cell cultures and was, like anhydropodorhizol, not converted into any detectable product. Deoxypodophyllotoxin, in contrast, was converted into podophyllotoxin, yielding significantly higher concentration than measured in whole plants.

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“…[35] Twenty four lignans have so far been reported from P. cubeba. [36,37,38,39,40,41] Lignans are an important group of secondary metabolites that are also assumed to contribute to the biological activity. Some of these lignans showed inhibitory activity against cytochrome P450 enzymes that are involved in the metabolism of all currently used drugs.…”

Section: Macroscopic Featuresmentioning

confidence: 99%