Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4

Chen, Yan; Liu, Zhaoming; Liu, Hongju; Pan, Yahong; Li, Jing; Liu, Lan; She, Zhigang

doi:10.3390/md16020054

Cited by 55 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optical density measurement for bacteria and fungus was recorded at 620 nm after incubation at 37 °C for 12 and 24 h, respectively. The minimal inhibitory concentration (MIC) was defined as the concentration at which the growth was inhibited 80% of the tested microorganisms [35].…”

Section: Methodsmentioning

confidence: 99%

New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus Aspergillus Sclerotiorum

Zhang

Kang

et al. 2019

Molecules

View full text Add to dashboard Cite

Three new γ-hydroxyl butenolides (1–3), a pair of new enantiomeric spiro-butenolides (4a and 4b), a pair of enantiomeric cyclopentenones (5a new and 5b new natural), and six known compounds (6–11), were isolated from Aspergillus sclerotiorum. Their structures were established by spectroscopic data and electronic circular dichroism (ECD) spectra. Two pairs of enantiomers [(+)/(–)-6c and (+)/(–)-6d] obtained from the reaction of 6 with acetyl chloride (AcCl) confirmed that 6 was a mixture of two pairs of enantiomers. In addition, the X-ray data confirmed that 7 was also a racemate. The new metabolites (1−5) were evaluated for their inhibitory activity against cancer and non-cancer cell lines. As a result, compound 1 exhibited moderate cytotoxicity to HL60 and A549 with IC50 values of 6.5 and 8.9 µM, respectively, and weak potency to HL-7702 with IC50 values of 17.6 µM. Furthermore, compounds 1−9 were screened for their antimicrobial activity using the micro-broth dilution method. MIC values of 200 μg/mL were obtained for compounds 2 and 3 towards Staphylococcus aureus and Escherichia coli, while compound 8 exhibited a MIC of 50 μ/mL towards Candida albicans.

show abstract

Section: Methodsmentioning

confidence: 99%

New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus Aspergillus Sclerotiorum

Zhang

Kang

et al. 2019

Molecules

View full text Add to dashboard Cite

show abstract

“…Cordyceps ninchukispora Beilschmiedia erythrophloia (Seeds) [17] 15. 5,7-dimethoxy-4-phenylcoumarin (28) Streptomyces aureofaciens CMUAc130…”

Section: -Methylcarbazole (2)mentioning

confidence: 99%

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

2020

View full text Add to dashboard Cite

A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

show abstract

“…New isocoumarins were also isolated from mangrove micromycete Ascomycota sp. [136], endophyte Pluchea indica. This strain was the source of three new isocoumarins, i.e., dichlorodiaportin (116), desmethyldichlorodiaportin (117), and desmethyldichlorodiaportinol (114), along with several other well-known analogs, i.e., dichlorodiaportinol (115) [137], desmethyldichlorodiaportin (119) [138], and dichlorodiaportin (120) [139,140].…”

Section: Other Polyketidesmentioning

confidence: 99%

Antibiotics from Extremophilic Micromycetes

et al. 2020

View full text Add to dashboard Cite

Extremophilic microorganisms, which are capable of functioning normally at extremely high or low temperatures, pressure, and in other environmental conditions, have been in the focus of microbiologists’ attention for several decades due to the biotechnological potential of enzymes inherent in extremophiles. These enzymes (also called extremozymes) are used in the production of food and detergents and other industries. At the same time, the inhabitants of extreme econiches remained almost unexplored for a long time in terms of the chemistry of natural compounds. In recent years, the emergence of new antibiotic-resistant strains of pathogens, which affect humans and animals has become a global problem. The problem is compounded by a strong slowdown in the development of new antibiotics. In search of new active substances and scaffolds for medical chemistry, researchers turn to unexplored natural sources. In recent years, there has been a sharp increase in the number of studies on secondary metabolites produced by extremophiles. From the discovery of penicillin to the present day, micromycetes, along with actinobacteria, are one of the most productive sources of antibiotic compounds for medicine and agriculture. Many authors consider extremophilic micromycetes as a promising source of small molecules with an unusual mechanism of action or significant structural novelty. This review summarizes the latest (for 2018–2019) experimental data on antibiotic compounds, which are produced by extremophilic micromycetes with various types of adaptation. Active metabolites are classified by the type of structure and biosynthetic origin. The data on the biological activity of the isolated metabolites are summarized.

show abstract

Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4

Cited by 55 publications

References 25 publications

New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus Aspergillus Sclerotiorum

New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus Aspergillus Sclerotiorum

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

Antibiotics from Extremophilic Micromycetes

Contact Info

Product

Resources

About