Dichlorophenol-containing pesticides and allergies: results from the US National Health and Nutrition Examination Survey 2005-2006

Jerschow, Elina; McGinn, Aileen P.; Vos, Gabriele de; Vernon, Natalia; Jariwala, Sunit; Hudes, Golda; Rosenstreich, David L.

doi:10.1016/j.anai.2012.09.005

Cited by 29 publications

(25 citation statements)

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“…Exposure to several insecticides and herbicides was reported to be associated with the presence of allergic rhinitis and atopic asthma 4,5,7 and dichlorophenols were associated with increased allergic sensitization to foods. 18 …”

Section: Discussionmentioning

confidence: 99%

“…16,17 Higher dichlorophenol levels in urine were associated with increased allergic sensitization to foods. 18 In addition, previous reports suggested that certain organochlorines preferentially induce the production in vitro of Th2- cytokines associated with increased allergic reactivity such as interleukin-4, and suppress the production of TH-1 cytokines that tend to block allergic reactivity, such as interferon-γ, interleukin2-, and interleukin-10. 19,20 …”

Section: Introductionmentioning

confidence: 99%

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Relationship between urine dichlorophenol levels and asthma morbidity

Jerschow

Parikh

McGinn

et al. 2014

Annals of Allergy, Asthma & Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between urine dichlorophenol levels and asthma morbidity

Jerschow

Parikh

McGinn

et al. 2014

Annals of Allergy, Asthma & Immunology

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“…Prior NHANES studies have examined urinary 2,5-DCP in relation with allergies,9 asthma,10 diabetes,11 obesity,13 14 metabolic syndrome12 and thyroid function,15 16 while 2,4-DCP has been examined in relation to allergies,9 asthma,10 diabetes,11 obesity13 14 and olfactory dysfunction 18. In the prior NHANES analysis of DCP and diabetes, there was a dose-dependent association between urinary 2,5-DCP quartiles and higher diabetes prevalence; 2,4-DCP was not related to diabetes prevalence 11.…”

Section: Discussionmentioning

confidence: 99%

“…2,4-DCP has been included in only some of these NHANES analyses. Higher urinary concentrations of 2,4-DCP were associated with greater prevalence of allergies9 and olfactory dysfunction18 but were not associated with prevalence of metabolic syndrome12 or obesity in adults13 or children,14 or with age of menarche among adolescent girls 17. In addition to NHANES, 2,5-DCP has been positively associated with prevalent respiratory diseases among boys (but not girls) aged 6–7 years old,19 while 2,5-DCP and 2,4-DCP were not associated with inflammatory biomarkers among pregnant Puerto Rican women 20.…”

Section: Introductionmentioning

confidence: 93%

“…Prior NHANES analyses have reported associations of higher concentrations of 2,5-DCP with greater prevalence of asthma (among atopic wheezers),9 allergies10 and metabolic abnormalities such as diabetes,11 metabolic syndrome,12 obesity,13 14 adverse concentrations of thyroid function biomarkers among both adult15 and adolescent16 participants and with younger age of menarche among adolescent girls 17. 2,4-DCP has been included in only some of these NHANES analyses.…”

Section: Introductionmentioning

confidence: 99%

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Urinary 2,5-dicholorophenol and 2,4-dichlorophenol concentrations and prevalent disease among adults in the National Health and Nutrition Examination Survey (NHANES)

et al. 2018

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ObjectiveTo test cross-sectional associations between urinary concentrations of 2,5-dichlorophenol (2,5-DCP) and 2,4-dichlorophenol (2,4-DCP) with the prevalence of cardiovascular disease (CVD), cancer, lung disease, thyroid problems and liver conditions.MethodsLogistic regression was used to evaluate associations of urinary concentrations of 2,5-DCP and 2,4-DCP with prevalence of various medical conditions among 3617 National Health and Nutrition Examination Survey participants from 2007–2008 and 2009–2010. ORs and 95% CIs for each disease were estimated. All regression models were adjusted for urinary creatinine.ResultsWe observed a monotonically increasing association between quartiles of 2,5-DCP and prevalence of CVD. After adjustment for sociodemographic and lifestyle characteristics, participants with the highest versus lowest quartile of urinary 2,5-DCP had an OR=1.84 (95% CI 1.26 to 2.70) (p linear trend=0.006). The association was similar with further adjustment for established clinical CVD risk factors. Higher 2,5-DCP was also associated with prevalence of all cancers combined (ORQ4 vs Q1=1.50 (95% CI 1.00 to 2.26); p trend=0.05) and, in exploratory analyses, with gynaecological cancers (ORQ4 vs Q1=4.15 (95% CI 1.51 to 11.40; p trend=0.01)). No associations were detected between 2,5-DCP and lung diseases, thyroid problems or liver conditions, nor between 2,4-DCP and prevalent disease.ConclusionIn this nationally representative study, higher urinary 2,5-DCP concentrations were associated with greater prevalence of CVD and all cancers combined. Further examination may be warranted to assess whether chronic exposure to 2,5-DCP is associated with incidence of adverse health outcomes.

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