Dick-Toxin-Ähnliches Gift in Filtraten von Bouillonkulturen Verschiedener Bakterien

Product of Staphylococcus aureus Responsible for the Scalded-Skin Syndrome

“…Exfoliatin is distinct from the alpha and delta toxins which are usually produced by human S. aureus strains. The reports of earlier investigators (1,3,4,8,9,10) claiming to demonstrate an erythrogenic toxin in culture supernatant fluids appear to have resulted from the presence of alpha toxin. These workers were able to destroy activity of supernatant fractions by heating at 56 to 61 C or neutralize activity with commercial antitoxin.…”

“…Discussions with experienced clinicians indicate that, although rare, a scarlatiniform rash associated with Staphylococcus aureus infection occurs more frequently than the literature suggests. Attempts to demonstrate an erythrogenic toxin comparable to those produced by group A streptococci have been reported (1, 3,4,8,9,10), but these attempts with crude culture filtrates cannot be interpreted. because at least two other products, the alpha and delta toxins, can elicit erythematous dermal responses, and most S. aureus strains of human origin produce these products.…”