Diclofenac in the treatment of pain after caesarean delivery

Olofsson, Christina; Legeby, M.; Nygårds, Eva-Britt; Östman, Katriina M.

doi:10.1016/s0301-2115(99)00144-x

Cited by 58 publications

(44 citation statements)

References 19 publications

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“…Previous studies demonstrating the opioid-sparing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) have been published but there has been no prior study on the epidural local anesthetic-sparing effect of NSAIDs. 7,8 Our data show a significant difference in the volume of local anesthetic solution used between six to 18 hr post-operatively. Residual operative analgesia may account for the similar volumes of local anesthetic solution used in the first six hours post-operatively.…”

Section: Discussionmentioning

confidence: 64%

Single dose diclofenac suppository reduces post-Cesarean PCEA requirements

Lim

Chong

et al. 2001

Can J Anesth/J Can Anesth

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Purpose: To assess the analgesic efficacy of administering, immediately after surgery, a single dose of diclofenac (100 mg suppository) to women who had undergone lower segment Cesarean section (LSCS) under combined spinal-epidural anesthesia, and received post-operative patient-controlled epidural analgesia (PCEA) with ropivacaine 0.2% and fentanyl 2 µg·ml -1 .Methods: Forty-eight ASA physical status I or II term parturients scheduled for elective LSCS under regional anesthesia were enrolled into this randomised double-blind study. The patient-controlled epidural analgesia device was programmed to deliver a bolus of 4 ml of local anesthetic mixture with a lockout period of ten minutes and an hourly limit of 12 ml. There was no baseline infusion. The study commenced upon the patient's first demand for analgesia post-operatively and the patients were assessed at one, six, 12 and 24 hr post-operatively for pain scores on movement, dermatomal level of sensory blockade, degree of motor blockade and volume of local anesthetic used. At conclusion of the study, patients' satisfaction scores were recorded.Results: The two groups of patients were similar demographically. Patients who received a diclofenac suppository used 52.8 ± 17.8 ml of local anesthetic mixture while those who did not, used 74 ± 25 ml (P <0.005). Pain scores and satisfaction scores did not differ significantly between the groups.Conclusion: A single administration of 100 mg diclofenac suppository is effective in reducing post-Cesarean epidural local anesthetic/opioid requirements by 33% for the first 24 hr post-operatively.

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Section: Discussionmentioning

confidence: 64%

Single dose diclofenac suppository reduces post-Cesarean PCEA requirements

Lim

Chong

et al. 2001

Can J Anesth/J Can Anesth

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“…This confirmed similar studies which revealed that diclofenac is an effective analgesia for the control of postoperative pain. 12,77,85,86 The progressive reduction of the pain score over the first 24 hours in both groups also confirmed that diclofenac given at repeated doses is effective for post-caesarean section pain control which is usually severe in the first 24 to 48 hours of the puerperium. 12,77,85,86 This is possibly because the peak plasma concentration of diclofenac is high up to 12 hours post-administration.…”

mentioning

confidence: 67%

“…Though the mechanism of action of the two analgesic agents: rectal diclofenac sodium and intramuscular diclofenac sodium are similar, the advantages of using suppository include their ease of administration, painless application and there is no need for injection devices. 12,13,14 . This study was designed to compare the relief of pain following caesarean section using similar analgesic agents, but different routes of administration.…”

Section: Introductionmentioning

confidence: 99%

Rectal Versus Intramuscular Diclofenac Sodium for Pain Relief Following Caesarean Section: A Randomised Controlled Trial

Adebayo¹

2018

jmscr

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“…Sezaryen operasyonu sonrası, insizyon bölgesindeki ağrılar annenin günlük yaşam aktiviteleri dahil, bebeğini emzirmesine kadar birçok yaşamsal fonksiyonunu yerine getirmesini engeller (Saunders 1999). Bu nedenle sezaryen sonrası kısa sürede annenin bebeği ile ilgilenebilecek duruma gelmesi için, ağrının kontrol altına alınması gerekmektedir (Olofsson, Legeby, Nygards and Ostman 2000).…”

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