Diclofenac–tramadol vs. diclofenac–acetaminophen combinations for pain relief after caesarean section

Mitra, Sukanya; Khandelwal, Purva; Sehgal, Alka

doi:10.1111/j.1399-6576.2012.02663.x

Cited by 44 publications

(44 citation statements)

References 11 publications

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“…The diclofenac + tramadol combination was overall more efficacious but associated with higher incidence of post-operative nausea. 28 In our study the incidence of nausea was 3% in tramadol group but increased to 10% in the tramadol + NSAID group (tramadol + piroxicam).…”

Section: Discussionmentioning

confidence: 40%

Tramadol and its combination with piroxicam in post-cesarean pain management: a comparative study

Ambika

Mamatha

Prabha

2017

Int J Basic Clin Pharmacol

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Background: Cesarean delivery is a major surgical procedure, requiring high quality pain relief to facilitate early ambulation, infant care and prevention of post-operative morbidity. There is no gold standard for post-cesarean pain management.Methods: Cases were randomly assigned to 2 groups of 30 cases each. One group received Tramadol 100mg and another, Tramadol 100mg+ Piroxicam 20mg. Injections were given intramuscularly, postoperatively after skin closure. Diclofenac 75mg was the rescue analgesia. Primary outcome measure was control of pain, assessed by visual analogue scale (VAS). Secondary outcomes were sedation and time to rescue analgesia. Safety of the drugs was assessed by adverse drug reactions. Data was analysed by student’s t test, analysis of variance and post-hoc test.Results: Multimodal group showed better analgesia compared to unimodal group (p<0001). Drowsiness was the main adverse effect in both treatment groups.Conclusions: Multimodal analgesic combination of tramadol and piroxicam showed superior analgesic effect with better pain control and longer duration of action compared to tramadol alone.

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Section: Discussionmentioning

confidence: 40%

Tramadol and its combination with piroxicam in post-cesarean pain management: a comparative study

Ambika

Mamatha

Prabha

2017

Int J Basic Clin Pharmacol

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“…In the study conducted by Mitra et al [18], tramadol-diclofenac was associated with comparable side effects with tramadolparacetamol and higher incidence of post-operative nausea. Use of rescue analgesic intake was similar between two groups (P = 0.872).…”

Section: Daymentioning

confidence: 88%

“…Mitra et al [18] have showed that diclofenac-tramadol and diclofenacparacetamol combinations are effective in providing postoperative pain control after caesarean section. The investigators demonstrated that the overall efficacy of diclofenac-tramadol combination is better than diclofenac-paracetamol.…”

Section: Daymentioning

confidence: 99%

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Comparative Efficacy and Safety Evaluation of Tramadol plus Diclofenac versus Tramadol plus Paracetamol in a Subgroup of Indian Patients with Moderate to Severe Acute Musculoskeletal Pain: A Phase III, 5 Day Open Label Study

Billa¹

2017

JESO

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“…Although multimodal analgesic combinations are well accepted, finding the right combination remains the key challenge. 9 We explored multimodal approach to pain relief after cesarean section using two different drugs with different routes of administration and mechanisms of action. We therefore compared the analgesic and side effect profile of intramuscular pentazocine alone or in combination with piroxicam.…”

Section: Introductionmentioning

confidence: 99%

Pentazocine versus pentazocine with piroxicam for postoperative pain relief after cesarean section: an open label, comparative study

Ambika

Mamatha

Prabha

2017

Int J Basic Clin Pharmacol

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Background: The concept of multimodal analgesia was introduced more than a decade ago as a technique to improve analgesia and reduce the incidence of opioid-related adverse events. The rationale for this strategy is the achievement of sufficient analgesia due to the additive or synergistic effects between different classes of analgesics. Objectives of the study was to compare the efficacy and safety of pentazocine and its combination with piroxicam in the management of post cesarean pain.Methods: Cases were randomly assigned to 2 groups of 30 cases each. One group received pentazocine 30mg and another; pentazocine 30mg + piroxicam 20mg. Injections were given intramuscularly, postoperatively after skin closure. Diclofenac 75mg was the rescue analgesia. Primary outcome measure was control of pain, assessed by visual analogue scale (VAS). Secondary outcomes were sedation and time to rescue analgesia. Safety of the drugs was assessed by adverse drug reactions. Data was analysed by student’s t test, analysis of variance and post-hoc test.Results: Multimodal group showed better analgesia compared to unimodal group (p<0001). Drowsiness was the main adverse effect in both treatment groups.Conclusions: Multimodal analgesic combination of pentazocine and piroxicam showed superior analgesic effect with better pain control and longer duration of action compared to pentazocine alone.

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Diclofenac–tramadol vs. diclofenac–acetaminophen combinations for pain relief after caesarean section

Abstract: Both diclofenac-tramadol and diclofenac-acetaminophen combinations can achieve satisfactory post-operative pain control in women undergoing caesarean section. The diclofenac-tramadol combination was overall more efficacious but associated with higher incidence of post-operative nausea.

Cited by 44 publications

References 11 publications

Tramadol and its combination with piroxicam in post-cesarean pain management: a comparative study

Tramadol and its combination with piroxicam in post-cesarean pain management: a comparative study

Comparative Efficacy and Safety Evaluation of Tramadol plus Diclofenac versus Tramadol plus Paracetamol in a Subgroup of Indian Patients with Moderate to Severe Acute Musculoskeletal Pain: A Phase III, 5 Day Open Label Study

Pentazocine versus pentazocine with piroxicam for postoperative pain relief after cesarean section: an open label, comparative study

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