Did decades of glyphosate use have selected for resistant amphibians in agricultural habitats?

Tartu, Sabrina; Renoirt, Matthias; Cheron, Marion; Léa-Lise, Gisselmann; Solenn, Catoire; Brischoux, François

doi:10.1016/j.envpol.2022.119823

Cited by 3 publications

(16 citation statements)

References 58 publications

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“…We have previously reported that AMPA exposure in tadpoles from the present study, increased deformity rate in individuals originating from AMPA-free forest and increased development length in AMPA-exposed individuals originating from agricultural sites (Tartu et al, 2022).…”

Section: Effects Of Agrochemicals According To Gut Microbiota Composi...supporting

confidence: 61%

“…One may hypothesize that those females in better body condition originate from habitats preserved from AMPA exposition (i.e. forest sites, see Tartu et al (2022)), and that their gut bacterial composition would be more sensitive to AMPA-exposure, however maternal body-condition was not related to habitat (agricultural vs. forested, LME estimate: -2.31 ± 3.69, p = 0.538). The observed relationships underline the dependence of the gut microbiome on interactions among other deterministic factors that were not accounted for in this study, such as host genetic and epigenetic background, age, diet or other environmental stressors (Chen et al, 2022; Shu et al, 2019; Song et al, 2021; Zhou et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…While embryonic stages may be more sensitive to AMPA exposure in forest individuals (AMPA-preserved population) they might be more resilient to a gut microbiome dysbiosis as no further effects on fitness were observed (Tartu et al, 2022). In contrast, agricultural individuals (AMPA-exposed population) could be more resistant during embryonic stages, but still, a gut microbiome dysbiosis, could lead to SCFA alteration and thus a longer duration to develop (Tartu et al, 2022). These findings once more underline the part that may play the hosts genotype in shaping the consequences of a gut microbiota dysbiosis.…”

Section: Effects Of Agrochemicals According To Gut Microbiota Composi...mentioning

confidence: 99%

“…While embryonic stages may be more sensitive to AMPA exposure in forest individuals (AMPA-preserved population), they might be more resilient to a gut microbiome dysbiosis as no further effects on fitness were observed at metamorphosis (Tartu et al, 2022). In contrast, agricultural individuals (AMPA-exposed population) could be more resistant during embryonic stages.…”

Section: Effects Of Agrochemicals Transformation Products According T...mentioning

confidence: 99%

“…The 120 spined toad tadpoles used presently are a subset of the 240 individuals employed in a previous companion study (Tartu et al, 2022). Study sites, parent captures, and housing conditions have been described elsewhere (Tartu et al, 2022). Briefly, between 28/01/21 and 22/02/21, we searched for spined toad amplectant pairs at night in four different sites (two agricultural sites and two sites surrounded by woodlands, see supporting information in (Tartu et al, 2022)).…”

Section: Fieldworkmentioning

confidence: 99%

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Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

Tartu,

Pollet,

Clavereau

et al. 2023

Preprint

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Glyphosate’s primary metabolite, aminomethylphosphonic acid (AMPA) is the most detected pollutant in surface waters. Recent studies have raised concerns regarding its toxicity, yet the involved underlying mechanisms remain poorly understood. A disruption of the gut microbiome, which plays a crucial role in host health, could be the mediator of most adverse effects. We investigated the impact of AMPA exposure on the gut microbiome of spined toad tadpoles (Bufo spinosus). We hypothesized that AMPA could alter the gut microbiota composition and that these effects could depend on the microbiota source. We exposed tadpoles to minute concentrations of AMPA and analyzed their faecal microbiota using 16S rRNA gene sequencing as a proxy of the gut microbiota. AMPA exposure decreased the gut bacterial biomass and affected bacterial community composition of tadpole’s faeces. Furthermore, we observed interactions between AMPA exposure and maternal body condition on the Bacteroidota and Actinobacteriota phyla abundances. This suggests a maternal effect on early-life microbial colonizers that could influence the response of the gut microbiome to AMPA. These findings highlight the importance of considering the gut microbiome when studying the effects of environmental contaminants. Further research is needed to elucidate the long-term implications of this microbiome alteration for amphibian health.

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Section: Effects Of Agrochemicals According To Gut Microbiota Composi...supporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Effects Of Agrochemicals According To Gut Microbiota Composi...mentioning

confidence: 99%

Section: Effects Of Agrochemicals Transformation Products According T...mentioning

confidence: 99%

Section: Fieldworkmentioning

confidence: 99%

See 3 more Smart Citations

Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

Tartu,

Pollet,

Clavereau

et al. 2023

Preprint

Self Cite

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Colouration matters in dull toads: ultraviolet adornment for ladies and agrochemicals fading effects

Tartu,

Lorrain-Soligon,

Cheron

et al. 2023

Oecologia

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Aquatic ecotoxicity of glyphosate, its formulations, and co-formulants: evidence from 2010 to 2023

Klátyik,

Simon,

Oláh

et al. 2024

Environ Sci Eur

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Glyphosate (GLY), the most widely used herbicide active ingredient (AI) in the world, is frequently detected in aquatic environments where it can affect non-target organisms. Globally, more than 2000 commercial GLY-based herbicides (GBHs) are used to control weeds. Non-target organisms are exposed to complex pesticide formulations under real environmental conditions, but the co-formulants contained in GBHs are classified as so-called inert and inactive ingredients in terms of their biological effects. The main objective of this comprehensive review is to compile the results of aquatic ecotoxicological studies on the side-effects of GLY, GBHs, and their formulating agents. Based on the results demonstrated for a variety of plant and animal aquatic organisms, oxidative stress appears to be a major trigger for these adverse effects, affecting the integrity of DNA and other biochemical functions. Furthermore, there is evidence of impairment of various physiological and behavioral functions. Adverse effects of GLY and GBHs have been observed even at very low concentrations. There are also differences in the sensitivity of the aquatic organisms tested, even with similar lifestyles, habitats or identical taxa. The studies typically investigate the short-term effects of a single exposure to GLY/GBH on a single species, whilst in reality multiple applications of GBHs together with other pesticides are common during a cropping cycle. Moreover, the interactions between GLY/GBHs and other aquatic contaminants are rarely studied. Higher toxicity of GBHs compared to GLY alone has often been observed, demonstrating that co-formulants can be highly toxic on their own and markedly increase the toxicity of the GBH formulation. The possible impurities in GBHs, such as heavy metals, can cause additional problems for the environment and food safety. The widespread and massive use of GBHs leads to increased exposure and environmental hazards. In addition, the need for a revision of the risk assessment system is emphasized. According to the results of aquatic ecotoxicological studies, the current use and pollution of the aquatic environment by GLY/GBHs is highly problematic and cannot be considered environmentally sustainable. It is, therefore, necessary to at least tighten the permitted forms of use.

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Did decades of glyphosate use have selected for resistant amphibians in agricultural habitats?

Cited by 3 publications

References 58 publications

Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

Colouration matters in dull toads: ultraviolet adornment for ladies and agrochemicals fading effects

Aquatic ecotoxicity of glyphosate, its formulations, and co-formulants: evidence from 2010 to 2023

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