Didodecyldimethylammonium Bromide Role in Anchoring Gold Nanoparticles onto Liposome Surface for Triggering the Drug Release

Cholesterol Levels Affect the Performance of AuNPs-Decorated Thermo-Sensitive Liposomes as Nanocarriers for Controlled Doxorubicin Delivery

“…Anionic AuNPs were selected to functionalize L since they are less cytotoxic than the cationic ones [37]. Cationic L were prepared since they can improve the electrostatic interaction with the anionic AuNPs [1,38]. [39] using analytical grade reagents.…”

“…Advanced nanomaterial therapeutic systems have several advantages over conventional therapeutic systems. Targeted delivery of drugs to specific sites of action constitutes a promising alternative in order to overcome the current limitations of drugs [ 1 ] and comprises a big challenge for researchers in the field of pharmaceutical sciences, which have witnessed great progress in the development of improved drug delivery systems, including lipid-based and polymer-based carriers [ 2 , 3 ].…”

“…Temperature-responsive L can be prepared with phospholipids that show a gel-to-liquid crystalline phase transition a few degrees above physiological temperature [ 12 ]. Among them, 1,2-dipalmitoyl- sn -glycero-3-phosphocholine (DPPC) has been widely used for obtaining these temperature-sensitive liposomal systems due to its low phase transition temperature, which is around 41 °C [ 1 ]. Moreover, hybrid nanomaterials composed of both inorganic/organic components have recently been studied as promising platforms for therapeutic applications, which also have been explored in the development of temperature-responsive hybrid nanocarriers.…”

“…To anchor AuNPs onto the surface of L, an appropriate modification of bilayer composition to confer them surface charge needs to be performed. Lipids containing opposite charges have been considered as a component of L [ 1 ] and didodecyldimethylammonium bromide (DDAB), a synthetic cationic lipid, has been employed. It is a homolog double-chain useful to prepare lipid vesicles in aqueous media and other membrane models, and it has been widely studied since it can form stabilized cationic L [ 1 , 20 , 21 ].…”

“…Lipids containing opposite charges have been considered as a component of L [ 1 ] and didodecyldimethylammonium bromide (DDAB), a synthetic cationic lipid, has been employed. It is a homolog double-chain useful to prepare lipid vesicles in aqueous media and other membrane models, and it has been widely studied since it can form stabilized cationic L [ 1 , 20 , 21 ]. Moreover, the presence of cholesterol plays a key role when stabilized L are prepared.…”