Die akute Wirkung des Diureticums Fursemid auf das Glomerulumfiltrat, die renale H�modynamik, die Wasser-, Natrium-, Chlorid- und Kaliumausscheidung und auf den Sauerstoffverbrauch der Nieren

Vorburger, C

doi:10.1007/bf01488664

Cited by 54 publications

(11 citation statements)

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“…This secondary fall in renal haemodynamics may be related to diuretic-induced extracellular volume depletion, since it could be partly counteracted by volume replacement (Figure 6). It thus appears that in the unanaesthetized, sodiumrepleted rat, furosemide does not cause any persistent increase in total renal blood flow, as has been demonstrated in other mammalian species (Vorburger, 1964;Hook et al, 1966;Ludens et al, 1968;Stowe & Hook, 1970). However, this apparent discrepancy among studies may to some extent be artifactual, since most studies reporting an increase of RBF or RPF were performed in anaesthetized animals having a low baseline RBF; also many studies were not controlled for bladder dead space Time (min) Figure 5 Effects of furosemide bolus injections (0.5, 7.5 and 120mgkg-1) on inulin clearance, tetraethylammonium (TEA) clearance, filtration fraction (FF) and fractional proximal Na excretion (FEN Furosemide may influence the intrarenal blood flow distribution as well as the total renal blood flow.…”

Section: Dsonsupporting

confidence: 62%

“…Thus, parameters estimating RBF or RPF have been shown to increase (Vorburger, 1964;Hook et al, 1966;Ludens et al, 1968;Stowe & Hook, 1970), remain unchanged (Tucker & Blantz, 1984;Gerber & Nies, 1980;Nies et al, 1983) or even decrease (present results) after furosemide administration. Undoubtedly, differences in species, Na intake, urine flow, anaesthesia, dosage, and mode of administration have contributed to the different results.…”

Section: Dsonsupporting

confidence: 48%

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Effects of furosemide on renal haemodynamics and proximal tubular sodium reabsorption in conscious rats

Christensen

Petersen

1988

British J Pharmacology

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1The effects of furosemide given as constant i.v. infusion (7.5mgkg1 h-) or bolus injections (O.5, 7.5 and 120mgkg 1) on renal haemodynamics and proximal tubular Na reabsorption were studied in conscious water diuretic rats. The clearance of Li (CLI) was used as marker for Na delivery from the proximal tubules, and clearance of [14C]-tetraethylammonium (CTEA) and [3H]-inulin (Ch.) as markers for renal plasma flow (RPF) and glomerular filtration rate (GFR), respectively. 2 Furosemide caused a transient increase of RPF and GFR followed by a secondary decrease below baseline levels; the latter could in part be counteracted by volume replacement. The filtration fraction (FF = GFR/RPF) was not significantly changed by furosemide. Fractional proximal Na excretion (CLVCh) was significantly increased by all doses of furosemide independent of changes in RPF, GFR and FF. 3 The peak diuretic/natriuretic effect of furosemide was markedly potentiated by volume replacement, probably due to prevention of antinatriuretic mechanisms triggered by volume depletion. 4 It is concluded that following i.v. furosemide administration there is a biphasic change in renal haemodynamics in conscious, restrained rats, and that the inhibition of proximal Na reabsorption, as manifested by changes in fractional Li excretion, is not likely to be due to changes in total renal haemodynamics.

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Section: Dsonsupporting

confidence: 62%

Section: Dsonsupporting

confidence: 48%

Effects of furosemide on renal haemodynamics and proximal tubular sodium reabsorption in conscious rats

Christensen

Petersen

1988

British J Pharmacology

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“…However, frusemide is an effective diuretic even in the presence of greatly impaired renal function (Vorburger, 1964;Muth, 1966;Reubi, 1966), and Vorburger (1964) has observed increases in GFR in patients in renal failure, with frusemide. A marked rise in renal blood flow occurs with frusemide (Schirmeister and Willmann, 1964;Vorburger, 1964;and Hook et al, 1966). Barger (1966) -Effect offrusemide on respiratory rate and weight.…”

Section: Discussion and Commentmentioning

confidence: 99%

Frusemide in heart failure of infancy

Richardson¹

1971

Archives of Disease in Childhood

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Richardson, Heather (1971). Archives of Disease in Childhood, 46, 520. Frusemide in heart failure of infancy. Twelve infants with heart failure and one with perinatal oedema were treated with intramuscular frusemide (1 0-1 -25 mg/kg). Frusemide was found to be a safe effective diuretic in infants with heart failure, resulting in clinical improvement, marked excretion of water, sodium, and chloride, with a lesser and more variable effect on potassium excretion. Complications were uncommon with this dose. The drug is most effective in acute pulmonary oedema or acute worsening of heart failure, but day-to-day control of persistent heart failure is more easily obtained by using repeated doses of oral or intramuscular frusemide plus, if needed, aldactone A or triamterene.There is little quantitative information on the use of frusemide in infancy. Reimold (1964) reports on its administration to 3 infants with perinatal oedema but observed little improvement; however, one infant aged 6 weeks, with heart failure due to myocarditis, responded well to a dose of 0 4-1 mg/kg of frusemide.Thieffry, Joly, and Ferchiou (1969) reported a significant diuresis and natriuresis in 8 infants with congenital heart disease, and 5 infants with other causes of fluid retention. In one infant, circulatory collapse was provoked, but they concluded that frusemide was a safe effective diuretic in a dose of 0 * 7-1 * 25 mg/kg. Therefore it was decided to carry out a further study to assess the usefulness of frusemide as a diuretic in a series of infants admitted with fluid retention predominantly due to heart failure.Short-term Studies Eleven infants aged 3 days to 6 months were studied. Details of diagnosis, sex, age on admission, and mode of presentation are given in Table I. The usual criteria for a diagnosis of heart failure were used (Lees, 1969); however, tachypnoea of more than 60 respirations per minute and cardiac enlargement on x-ray in patients with congenital heart disease were considered to be sufficient to make the diagnosis. Of the 11 infants, 9 were moderately to critically ill, their most striking clinical features being tachypnoea and exhaustion (Table II). Frusemide in a dose of 1 0-1-25 mg/kg was given intramuscularly under the following conditions.(a) Initially, when a diagnosis of heart failure was made; (b) when deterioration in an infant's condition occurred, usually associated with increasing tachypnoea, and clinically attributed to increasing heart failure; and (c) when an increase in weight of 2% total body weight occurred in a 12-hour period.At the time of initial examination, 8 of the children had been digitalized and one had received one dose of mersalyl. During the period of the study no other diuretic therapy other than frusemide was given.Control urines (24-hour) were obtained from all the infants on admission, and twice a week thereafter. This was relatively easy in male infants using Paul's tubing. In female infants urine collecting bags (Down Bros.) were employed with less successful results. Accordingly, a...

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“…imal site of action is conflicting (3,4) as are the data concerning glomerular filtration rate and renal plasma flow (5,6). The more recent observations (7) indicate that renal plasma flow is elevated if plasma volume is maintained during the diuresis.…”

mentioning

confidence: 99%

Redistribution of Renal Blood Flow Produced by Furosemide and Ethacrynic Acid

Birtch

Zakheim

Jones

et al. 1967

Circulation Research

162

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Outer medullary blood flow ( S5 Kr method) is markedly reduced by furosemide and ethacrynic acid injected into the renal artery of unanesthetized dogs; juxtamedullary cortical flow is also decreased. Anatomic localization of the redistribution was verified by autoradiography and by silastic injection studies. The injected specimens demonstrated a relative increase in the resistance of the peritubular capillaries of the juxtamedullary cortex and outer medulla, the blood supply of the juxtamedullary tubules, Henle's loops and collecting ducts; the vasa recta were dilated. Total renal blood flow (Doppler flowmeter) decreased 10% 1 min after injection, and then gradually began to increase at 2 to 3 min, reaching levels 25 to 30% above control as cortical blood flow increased. The vasodilatation in the cortex is probably localized in the pars radiata. The onset of the diuresis coincided with the decrease in renal blood flow, and persisted after total renal blood flow returned to control value. Thus, the time course of the diuresis correlated more closely with the sustained decrease in juxtamedullary and outer medullary blood flow.ADDITIONAL KEY WORDS diuretics diuresis vasa recta renal medulla unanesthetized dogs medullary blood flow peritubular capillaries• In an attempt to determine whether redistribution of renal blood flow may alter sodium and water excretion, we have studied the effects of the new potent diuretic agents, furosemide (4 chloro-N-[2-furyl methyl]-5sulfamyl-anthranilic acid) and ethacrynic acid (2, 3-dichloro-4-[2 methylenebutyl]-phenoxyacetic acid) on renal blood flow using the 85 Kr technique (1). These drugs abolish the concentrating ability of the kidney, and impair the diluting capacity; these effects suggest that a major site of action is in the ascending portion of the loop of Henle in the outer medulla (2). Evidence for a more prox-IOOK count/min O.IK Kr Disoppearance Curves CORTICAL \ CORTICAL A ANDB t B3 Kr INJECTED MINUTES FIGURE Comparison of the first 4 min of the S5 Kr disappearance curves following injection of the isotope into the renal artery of a control dog (dashed line), and a dog with a diuresis induced by furosemide (solid line). The graphic representation of the derived exponentials is shown in the lower portion of the figure.

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Die akute Wirkung des Diureticums Fursemid auf das Glomerulumfiltrat, die renale H�modynamik, die Wasser-, Natrium-, Chlorid- und Kaliumausscheidung und auf den Sauerstoffverbrauch der Nieren

Cited by 54 publications

References 2 publications

Effects of furosemide on renal haemodynamics and proximal tubular sodium reabsorption in conscious rats

Effects of furosemide on renal haemodynamics and proximal tubular sodium reabsorption in conscious rats

Frusemide in heart failure of infancy

Redistribution of Renal Blood Flow Produced by Furosemide and Ethacrynic Acid

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