Die Amidinstruktur in der Arzneistofforschung

Amidines and related compounds. 6. Structure-activity relations of antihypertensive and antisecretory agents related to clonidine

“…For preparation of 2c-e,g,j,m by this method, the products were isolated by distillation and the bases (oil) were converted to crystalline salts. Method C. 2 (2,6-Dimethylbenzyl)-2-imidazoline (4e). A mixture of 2.6-dimethyIphenylacetonitrile16 (2,1 g, 14.5 mmol) and ethvlenediamine mono-p-toluenesulfonate was heated at 190°for 2 hr when the evolution of NH3 ceased (indicated by pH paper).…”