Die Anwendung von Lävulinsäure und 5-Nitro-2-furylmethylendiacetat in der Totalsynthese einiger neuer biologisch aktiver (5-Nitro-2-furyl)azomethine

A bio-based click reaction leading to the dihydropyridazinone platform for nitrogen-containing scaffolds

“…This was probably caused by the presence of protons that polarized the carbonyl groups of LA to facilitate the imine formation. 37,38 All these features, e.g., mild conditions, fast reaction, high yield, one product, easy operation, water solvent, means our system outperforms the others in the previous literature, 35,36 and fulfilled the criteria of a click reaction, which has never been reported in biomass conversions before.…”

“…Thus, we envisioned DHMP crystal as a new platform for N-containing chemicals synthesis from biomass resources. Although some of the reported synthetic procedures involved the synthesis of DHMP as the fundamental step of drug molecule synthesis 35,36 , no detailed information about the reaction and product was provided, and there is still a distinct lack of comprehensive investigations into the synthesis and application of DHMP.…”

Tryptophan and thiosemicarbazide derivatives: design, synthesis, and biological evaluation as potential β-d-galactosidase and β-d-glucosidase inhibitors

“…1-2°C (Lit. 1-2°C, Vlaovic et al, 1990) General procedure for synthesis of acid hydrazides 9a and 9b…”

“…The solid was then washed with ethanol, dried, and recrystallized from ethanol (Yoshino et al, 2006;Vlaovic et al, 1990). General procedure for synthesis of thiosemicarbazide derivatives (11a-h) To a solution of 5.5 mmol of substituted acid hydrazides 9a or 9b in 30 mL of ethanol, 5.5 mmol of the appropriate aryl or alkylisothiocyanate 10 (isothiocyanatomethane, isothiocyanatobenzene, 1-isothiocyanato-4-methoxybenzene, 1-isothiocyanatonaphthalene, 1-isothiocyanato-4-nitrobenzene) was added.…”