Die Ausscheidung der C21-Steroide bei Neugeborenen

The Excretion of Neutral Steroids in the Urine of Newborn Infants

“…The major urinary metabolite of progesterone in the adult is pregnanediol, and large amounts of this compound are excreted in maternal urine in the third trimester. Zander & Solth (1953) could not detect pregnanediol in the urine of infants in the first days of life and showed that newborn infants do not excrete pregnanediol even after a loading dose of 20 mg. of progesterone. A 100 ml.…”

Relationship between Maternal Progesterones and the Delayed Drug Metabolism in the Neonate

“…It is possible, therefore, that the delayed development of drug metabolizing enzymes in the newborn infant is also associated with these reduced progesterone metabolites. The level of these metabolites in the fetus and newborn in the 1st day of life is also high [20], and the excretion and metabolism of these steroids is low [23][24][25][26]. In addi tion, the quantities of these reduced derivatives are being re-established by their intake in mother's milk.…”