Die Behandlung von SKAT-Non-Respondern mit einem Papaverin/Phentolamin/Prostaglandin E1-Gemisch

Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

“…Reported dosages of single compounds in several publications varied between 4.4 and 15 mg papaverine, 0.15 and 0.5 mg phentolamine, and 1.5 and 20 mg PGE 1 per ml. 8,57,58 Response rates with the trimix combination in non-selected patients with ED approached 80 ± 90% and were thus 10 ± 15% higher than after 20 mg alprostadil monotherapy. 57,59 Because rigid erections following trimix administration were achieved in 50 ± 62% of socalled non-responders, some authors suggested that trimix would be useful rescue therapy for nonresponders to monotherapy with alprostadil or the combination of papaverineaphentolamine.…”

“…57,59 Because rigid erections following trimix administration were achieved in 50 ± 62% of socalled non-responders, some authors suggested that trimix would be useful rescue therapy for nonresponders to monotherapy with alprostadil or the combination of papaverineaphentolamine. 8, 58 In two prospective trials the trimix combination was preferred by 46 ± 67% of patients compared to 19 ± 23% for the approved alprostadil sterile powder (Table 11). 60,61 In the author's hands, the trimix combination produces a response in 30 ± 40% of non-responders to 40 mg alprostadil.…”