Die Beziehungen zwischen Arcus lipoides der Hornhaut und Arteriosklerose

Presenile Corneal Arcus in Healthy Persons. A Possible Cardiovascular Risk Indicator in Younger Adults

“…The latter view, however, cannot be true, since the prevalence of lipid-abnormalities in the total population (Wood et al 1972) does not at all reach that of arcus in the age group under study (39-49 years) (10-25%, Forsius 1954;Jaeger & Eisenhauer 1977). As concerns our own results, the higher mean cholesterol levels in the male and female arcus groups are in agreement with results, obtained by others (Cogan 1974;Immich et al 1967;Jaeger & Eisenhauer 1977;Rosenmann et al 1974). While the total occurrence of hypercholesterolemia (se.-cholesterol higher than 7.0 mmol/l) in the arcus group is 20% (males: 25%, females: 15%) (Table 11), the estimated occurrence of hypercholesterolemia (Fredencksson 11) in the general population is only 3.7% (Wood et al 1972).…”

“…Most authors agree upon the existence of a correlation between arcus and hypercholesterolemia in younger age-groups; this association, however, disappears in the older age-groups, where local corneal factors are thought to dominate in arcus-formation (Cogan 1974;Immich et al 1967;Parwaresch et al 1976;Rosenmann et al 1974).…”

“…Regarding the intermediate age-groups, opinions are diverging, one group of authors claiming lack of significance (Immich et al 1967), another an obligate co-existence of underlying lipid-abnormalities (Parwaresch et al 1976). The latter view, however, cannot be true, since the prevalence of lipid-abnormalities in the total population (Wood et al 1972) does not at all reach that of arcus in the age group under study (39-49 years) (10-25%, Forsius 1954;Jaeger & Eisenhauer 1977).…”

“…Most authors agree upon the existence of a correlation between arcus and hypercholesterolemia in younger age-groups; this association, however, disappears in the older age-groups, where local corneal factors are thought to dominate in arcus-formation (Cogan 1974;Immich et al 1967;Parwaresch et al 1976;Rosenmann et al 1974). Regarding the intermediate age-groups, opinions are diverging, one group of authors claiming lack of significance (Immich et al 1967), another an obligate co-existence of underlying lipid-abnormalities (Parwaresch et al 1976). The latter view, however, cannot be true, since the prevalence of lipid-abnormalities in the…”

“…Our present knowledge regarding corneal arcus in relation to lipid-abnormalities and cardiovascular diseaseideath dates from several sources. A connexion between arcus in pre-middle-age and acute myocardial infarction has been established in a large scale prospective population study, the Western Collaborative Study Group (Jaeger & Eisenhauer 1977), whereas others have reported a lack of connexion between atherosclerosis, verified by authopsy, and arcus-prevalence (Immich et al 1967).…”