Die biologische Wertigkeit von Walfleisch

Catalytic Self-Threading: A New Route for the Synthesis of Polyrotaxanes

“…The structure of the polymer threaded with the macrocycle and the strength of the noncovalent interaction between both determines if and to what extent the macrocycle can slide along the polymer main chain or side chain. [1][2][3][4][5] This latter design feature has been exploited to prepare thermoresponsive, [7][8][9] photoresponsive, [10][11][12][13] and pH-responsive 1,14,15 polyrotaxanes with an ultimate application as triggerable macromolecular switching devices. The appropriate choice of macrocycle and its level of threading influences the solution-phase 8,[16][17][18][19] and solid-state [16][17][18][19][20][21][22] behavior of the parent polymer, altering the solubility characteristics, 8,[16][17][18][19][23][24][25] phase behavior, 8,[16][17][18][19]23 and melt characteristics 26 as well as solution viscosities 8,[16][17]…”

“…Groups bulkier than cyclohexyl rings 108 and disubstituted aromatic sixmembered rings with the exception of 1,4-disubstituted ones are not included in the interior of cucurbit [6]uril. 80,83,84 We identified 2,4-bis(chloromethyl)-1,3,5trimethylbenzene (12), from which we could synthesize both the bisalkyne and the bisazido monomers ( Figure 12). N-{2,4,6-Trimethyl-3-[(2-propynylamino)methyl}-benzyl}-2-propyn-1-amine dihydrochloride (14) was synthesized via N-alkylation of propargylamine to yield crude 13 in 100% yield and directly converted to its HCl salt in 86% overall yield.…”

Benzoesäure [MAK Value Documentation in German language, 1995]

“…Die Fütterung von 1% Benzoesäure an Ratten über 4 Generationen zeigte keinen Einfluß auf Wachstum, Futterverwertung, Lebensdauer, Fortpflanzung, Organgewichte und auf das histologische Bild der Organe. Bei der Fütterung mit 0,5% Benzoesäure wurde eine Verlängerung der Lebensdauer beobachtet [30]. Eine 7tägige Fütterung von 362 ppm Benzoesäure an Ratten verursachte keine Änderung der Werte des mikrosomalen Leberproteins und Zytochrom-P-450 sowie der N-Demethylierung von Aminopyrin oder der p-Hydroxylierung von Anilin [31].…”