Die Bulbocapnin-Katatonie, ihre Synergisten und Antagonisten

The Antagonism of Methyl Phenidate and Iproniazid to Bulbocapnine Catatonia in the Rat

“…It is of interest that atropine and a number of other anticholinergic agents are effective in reducing the rigidity of reserpine-induced catatonies, but unlike methyl phenidate do not produce a locomotor response (Glow, 1959). Similar findings have been made with bulbocapnine-induced catatonic-like states {Zetler and Moog, 1958). It is clearly of some interest to speculate how it is that two such dissimilar compounds produce apparently identical behavioural effects and that in both cases various degrees of remission can be induced with administration of methyl phenidate.…”

“…Recent experiments (Zetler and Moog, 1958) have shown that reserpine and bulbocapnine can act synergistically. It was considered plausible that methyl phenidate may have an antagonistic action on bulbocapnine "catatonia".…”

Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum

“…Thus, mepyramine [16] or cyproheptadine [17] seem to be effective in delaying or attenuating neuroleptic-induced catalepsy in rats and diphenhydramine antagonizes bulbocapnine-mediated catalepsy in rats [18,19]. Moreover, other antihistamines of the same class as mepyramine found broad application in the therapy of Parkinsonian patients [20].…”