Die Endigungsweise des vegetativen Nervensystems

StöhrJr., Philipp

doi:10.1007/978-3-642-47923-6_7

Cited by 2 publications

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“…Occurrence of ample nerve fibers along the vascular wall in the islet of pancreas has been noticed since the early studies using silver impregnation techniques (HONJIN, 1956;STOHR, 1957), and later confirmed both by cholinesterase histochemistry (COUPLAND, 1958;LIBMAN and SUTHERLAND, 1965) and by Falck-Hillarp's method for monoamine detection (LEGG, 1968;CEGRELL, 1968). None of the previous authors, however, have dreamed of the possibility that nervous secretions might be released into the circulation here.…”

Section: Insular Neurosecretion and Its Implicationsmentioning

confidence: 94%

Proposal of a Neurosecretory System in the Pancreas

Fujita

Kobayashi

1979

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary. The nerve fibers supplying the islets of the dog pancreas were examined by electron microscopy. Axons with swollen portions containing various types of synaptic vesicles, including a cholinergic type, two varieties of presumable aminergic type and a possible peptidergic type, rush to the pericapillary space to end there, whereas only a small part of them seem to terminate on the endocrine cells of the islet.Schwann cell cytoplasm invests the axons and often separates these from the endocrine cells. The terminal portions filled with vesicles usually become free of the Schwann sheath on the side facing the blood capillary. Here the neuronal secretions are believed to be released into the blood stream through the pored endothelium of the capillary.The neurosecretions, together with the islet hormones are distributed to the exocrine pancreas in high concentrations via the insulo-acinar portal system. It seems thus sufficient for the nerves to supply the islet in order to control the exocrine function of the pancreas.During the three decades since the establishment of the hypothalamo-hypophyseal neurosecretory system by BARGMANN (1949), the concept and criteria of neurosecretion have changed a great deal (LEDERIS, 1974;SANO, 1978). BARGMANN and SCHARRER (1951) regarded that stain-technologically demonstrable secretory granules are essential for a neurosecretory cell, but later this criterion had to be abandoned as newly discovered neurosecretory system producing and transporting releasing hormones from the hypothalamus to the hypophyseal portal vessels revealed no stainable granules. Recent advance in the knowledge of peptidergic neurons and of aminecontaining neurons occurring in different central and peripheral nervous tissues caused further confusion to the concept of neurosecretion. In agreement with SANO (1978), the last reliable criterion of neurosecretion (in higher vertebrates) must be that the neuronal secretions are released into the circulation and this is morphologically reflected in that the nerve terminals are not related to their target organ or cell but end in the perivascular (especially pericapillary) space.In the course of our electron microscope study of the dog pancreas, we recently noticed that numerous nerve terminals occur in the pericapillary spaces of the islet. Also by re-examining the electron micrographs which we produced for our previous *This paper is dedicated to the memory of the late Professor Wolfgang BARGMANN. 277

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Section: Insular Neurosecretion and Its Implicationsmentioning

confidence: 94%

Proposal of a Neurosecretory System in the Pancreas

Fujita

Kobayashi

1979

Arch. Histol. Jap., Arch. Histol. Jpn

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“…W ährend man jedoch in geburtshilflichen Kreisen seit Walthard die «Am phora-Körperchen» kaum jem als angezweifelt hat, wurde ihre Existenz von anatom ischer Seite, zum Beispiel von Stöhr (1957) bestritten.…”

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Zur Problematik korpuskulärer Rezeptoren im Bereich des inneren weiblichen Genitale

Müller¹

1965

Gynecol Obstet Invest

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Die Endigungsweise des vegetativen Nervensystems

Cited by 2 publications

References 144 publications

Proposal of a Neurosecretory System in the Pancreas

Proposal of a Neurosecretory System in the Pancreas

Zur Problematik korpuskulärer Rezeptoren im Bereich des inneren weiblichen Genitale

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