Die Feinstruktur des exokrinen Pankreasgewebes vom Menschen

Kern, Horst F.; Ferner, Helmut

doi:10.1007/bf00968543

Cited by 37 publications

(10 citation statements)

References 12 publications

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“…Nach Z immermann [1927] Hlektronenmikroskopischc Untersuchungen befassen sich im Zusammenhang mit dem exkretorischen Teil der Bauchspeicheldrüse bei verschiedenen Haus-und Labortieren nur mit den feinen Anfangsstücken der Ausführungsgänge [Ekholm et a i. 1962: Ichikawa, 1965Kern und F erner, 1971;Amsterdam und Jamieson, 1974].…”

Section: Introductionunclassified

Die Feinstruktur des Epithels des Ductus pancreaticus major des Schafes

Weyrauch

Schnorr²

1976

Cells Tissues Organs

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Light- and electron-microscopic and some histochemical investigations on the epithelium of the ductus pancreaticus major were carried out in sheep. At least six different cell types are recognizable: (1) nondifferentiated duct cells; (2) cells containing apical secretory granules; (3) goblet cells; the mucosubstances of type 2 and 3 are PAS- and Alcian-blue-positive, also reacting with methenamine silver; (4) ciliated cells, containing a single cilium with the microtubular pattern 9 + 2; (5) tuft cells with extremely long and wide microvilli and a pear-shaped cell body; (6) migrating cells, mainly lymphocytes and some assumed eosinophils, showing reaction to Mg++-activated ATPase.

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Section: Introductionunclassified

Die Feinstruktur des Epithels des Ductus pancreaticus major des Schafes

Weyrauch

Schnorr²

1976

Cells Tissues Organs

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“…In human glands, inclusion bodies have been noted in parotid granules (Orzalesi, Riva, and Testa, 1971) but not in lacrimal secretory granules (Orzalesi et al, 1971) nor in pancreatic zymogen granules (Kern and Ferner, 1971), both of which have a homogeneous or finely granular structure.…”

Section: Discussionmentioning

confidence: 99%

Hypersecretion of zymogen granules in the pathogenesis of cystic fibrosis

Blomfield¹,

Dascalu²,

Lennep³

et al. 1973

Gut

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“…In addi tion to varying patterns of microvilli, a cen trally located cilium is observed protruding into the ductal lumen. Cilia are also described in the centroacinar cells of the human pancreas [Kern and Ferner, 1971], The purpose of this organelle, which has been also found in other tissues [Barnes, 1961;Bulger et al, 1974;Wilson and McWhorter, 1963;Polyzonis, 1970;Althoff et al, 1976], is not well understood. A single cilium in epithelial cells may either exist at one time during the cell life span [Rodin, 1974] or represent remnants of embryonic development.…”

Section: Discussionmentioning

confidence: 99%

“…The depth of focus in SEM also allows demonstration of the centroacinar portion, which shows numerous microvilli lining the lumen. The number of microvilli per cell surface is estimated to be 200-300 in man [Kern and Ferner, 1971]. Occasionally observed cilia in the lumen may well origi nate from 'intercalated' ductal cells which represent the beginning of the duct system.…”

Section: Discussionmentioning

confidence: 99%

Structure of the pancreas in Syrian hamsters

Ogrowsky¹,

Fawcett²,

Althoff³

et al. 1980

Cells Tissues Organs

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The Syrian hamster is a suitable animal model for the study of pancreatic neoplasms of ductal origin. Therefore, the present study was performed to obtain basic information on the pancreas of this species in neonatal life and during the aging process. Scanning electron-microscopic (SEM) examination showed that the islets of Langerhans could not be seen in the pancreas at day 15 of gestation or shortly after delivery, but developed during the first 14 postnatal days and doubled their size by 4 weeks after birth. In hamsters over 1 year of age, the islets of Langerhans attain a diameter of approximately 300 µm. Cells of the acini in the fetal pancreas already contain zymogen-like granules, their final size is reached by 28 days postpartum. Age does not markedly affect the epithelial cell height of the pancreatic ducts. Small ducts are lined with cuboidal large ducts with a columnar epithelium. The epithelial height correlates with luminal size which increases with age. The luminal surface of the ductal epithelium shows varying forms and density of microvilli, and usually a single, centrally located cilium. Mucus-producing cells, identified by droplets which protrude onto the cell surface, are first seen in the common duct of 4-week-old hamsters and are prominent in adult animals.

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Die Feinstruktur des exokrinen Pankreasgewebes vom Menschen

Cited by 37 publications

References 12 publications

Die Feinstruktur des Epithels des Ductus pancreaticus major des Schafes

Die Feinstruktur des Epithels des Ductus pancreaticus major des Schafes

Hypersecretion of zymogen granules in the pathogenesis of cystic fibrosis

Structure of the pancreas in Syrian hamsters

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