Die geburtshilflich-gynäkologische Bedeutung der Tetanie

Kehrer, E.

doi:10.1007/bf01986757

Cited by 43 publications

(4 citation statements)

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“…Classical neonatal tetany was first described by Kehrer in 1913 and subsequently shown to be associated with low serum calcium levels (Howland and Marriott, 1917). The babies in our study, however, did not form a homogeneous group and the majority were not considered to have the classical picture of neonatal hypocalcaemia.…”

Section: Resultscontrasting

confidence: 53%

Measurement of serum parathyroid hormone, with particular reference to some infants with hypocalcaemia

Fairney¹,

Jackson²,

Clayton³

1973

Archives of Disease in Childhood

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Section: Resultscontrasting

confidence: 53%

Measurement of serum parathyroid hormone, with particular reference to some infants with hypocalcaemia

Fairney¹,

Jackson²,

Clayton³

1973

Archives of Disease in Childhood

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“…Spontaneous abortion, stillbirth, and neonatal death have also occurred (25,170,302). The cord blood calcium is variably normal, low, or even increased, whereas the fetal parathyroids may be enlarged and hyperplastic.…”

Section: Human Datamentioning

confidence: 99%

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Kovacs

2014

Physiological Reviews

211

188

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Mineral and bone metabolism are regulated differently in utero compared with the adult. The fetal kidneys, intestines, and skeleton are not dominant sources of mineral supply for the fetus. Instead, the placenta meets the fetal need for mineral by actively transporting calcium, phosphorus, and magnesium from the maternal circulation. These minerals are maintained in the fetal circulation at higher concentrations than in the mother and normal adult, and such high levels appear necessary for the developing skeleton to accrete a normal amount of mineral by term. Parathyroid hormone (PTH) and calcitriol circulate at low concentrations in the fetal circulation. Fetal bone development and the regulation of serum minerals are critically dependent on PTH and PTH-related protein, but not vitamin D/calcitriol, fibroblast growth factor-23, calcitonin, or the sex steroids. After birth, the serum calcium falls and phosphorus rises before gradually reaching adult values over the subsequent 24 -48 h. The intestines are the main source of mineral for the neonate, while the kidneys reabsorb mineral, and bone turnover contributes mineral to the circulation. This switch in the regulation of mineral homeostasis is triggered by loss of the placenta and a postnatal fall in serum calcium, and is followed in sequence by a rise in PTH and then an increase in calcitriol. Intestinal calcium absorption is initially a passive process facilitated by lactose, but later becomes active and calcitriol-dependent. However, calcitriol's role can be bypassed by increasing the calcium content of the diet, or by parenteral administration of calcium.

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“…[229][230][231][232][233] Spontaneous abortion, stillbirth, and neonatal death have also occurred. [234][235][236] The fetal parathyroids are enlarged and hyperplastic, and the cord blood calcium may be normal, low, or even increased. Autonomous parathyroid function may persist and cause hypercalcemia and skeletal demineralization in the neonate before eventually subsiding to normal.…”

Section: Hypoparathyroidism In the Mothermentioning

confidence: 98%

Parathyroid Function and Disease during Pregnancy, Lactation, and Fetal/Neonatal Development

Kovacs

2015

The Parathyroids

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Die geburtshilflich-gynäkologische Bedeutung der Tetanie

Cited by 43 publications

References 0 publications

Measurement of serum parathyroid hormone, with particular reference to some infants with hypocalcaemia

Measurement of serum parathyroid hormone, with particular reference to some infants with hypocalcaemia

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Parathyroid Function and Disease during Pregnancy, Lactation, and Fetal/Neonatal Development

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