Die Gewichtsregulation im Rahmen der Anorexia nervosa unter besonderer Berücksichtigung der Leptinsekretion

Abstract

Underweight is a key symptom in anorexia nervosa. In this review we summarize recent findings pertaining to weight regulation in this eating disorder. The observation that a body mass index below 13 kg/m2 upon admission for inpatient treatment is associated with a high mortality rate and chronic persistence of underweight is of obvious clinical relevance. A lowered leptin secretion, which results from the weight loss, is presumably of major importance for the development of amenorrhea. We discuss findings pertaining to a reduced body weight in other psychiatric disorders during adolescence in the light of Kretschmer's findings related to body frame and psychopathology.

Leptin und psychiatrische Erkrankungen

“…Anorexia nervosa [15] ist die am intensivsten erforschte Essstörung und tritt bei 1% der weiblichen Bevölkerung in Industriestaaten auf. Die wichtigsten diagnostischen Symptome sind Untergewicht und Amenorrhoe.…”

Variability of Leptin Values Measured from Different Sample Matrices

“…It is produced by differentiated adipocytes, the placenta and the stomach and has predominantly signal function to the central nervous system [1, 2, 3, 4]: leptin plasma concentrations reflect the body fat content and are positively correlated with the body mass index [5, 6, 7]. In the hypothalamus leptin suppresses food intake and stimulates energy turnover [1, 8, 9]. Specific receptors have been found ubiquitously in the body (e.g.…”