Die Krampfwirkung des Curarins

Injections of drugs into the lateral ventricle of the cat

“…On the other hand, there are a number of observations showing that central effects like those observed on intraventricular injection can occur when the drug is given intravenously or by mouth. Central actions of curare similar to those here described have been reported on subcutaneous, intramuscular, intravenous or intra-aortic injections (Tillie, 1890;Joseph & Meltzer, 1912;Blume, 1934;Cohnberg, 1946), and poisoning by atropine produces, in man, a state of delirium and excitation which is, to some extent, a counterpart of the effects seen in the behaviour of the cat after intraventricular injection of this substance. It would be interesting to know whether a large output of PH.…”

Sleep induced by small doses of tubocurarine injected into cerebral ventricles of dog

“…This may explain the controversial claims that tubocurarine has excitatory, inhibitory or no central effects on systemic administration. Blume (1934), Cohnberg (1946) and McCawley (1949) described excitatory effects in dogs and rats after systemic administration of tubocurarine. After intravenous injection of tubocurarine in dogs, McIntyre, Dunn & Tullar (1946) described an initial increase in the activity of E.E.G.…”