Die mikroanalytische Schnellbestimmung von Halogenen und Schwefel in organischen Verbindungen

Schöniger, Wolfgang

doi:10.1007/bf01262130

Cited by 316 publications

(37 citation statements)

References 6 publications

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“…In this work, the DSs of the pectin sulfates were determined by the barium sulfate nephelometry method. 29 Pectin sulfate (0.030 g) was weighed accurately. HCl (10 mL, 0.1 mol/L) was added to hydrolyze the sulfate groups of pectin sulfate at 100 C for 8 h. After the obtained solution was evaporated to dryness, 10.00 mL of distilled water was added with stirring to dissolve the residue.…”

Section: Measurement Of Dsmentioning

confidence: 99%

Synthesis and anticoagulant activity of pectin sulfates

Fan

Gao

Wang

et al. 2011

J of Applied Polymer Sci

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In this article, we describe the first use of trisulfonated sodium amine as a sulfating reagent for preparing pectin sulfate in aqueous solution. The main reaction parameters that were expected to affect the degree of substitution (DS) were studied. The optimal reaction conditions for the synthesis of pectin sulfate were found to be as follows: the pH of the reaction medium, the reaction temperature, the reaction time, and the ratio of the mole of sodium nitrite (n NaNO2 ) to the mass of pectin (m pectin ) were 6, 60 C, 12 h, and 2.5/190 mol/g, respectively. Pectin and pectin sulfate were characterized by Fourier transform infrared (FTIR) spectroscopy and 13 C-NMR. The FTIR spectra showed the characteristic absorptions of sulfate ester bonds at 1264 and 830 cm À1 . Furthermore, the anticoagulant activity of pectin sulfates with different DSs, concentrations, and molecular weights were investigated with respect to the activated partial thromboplastin time (APTT), thrombin time (TT) and prothombin time. The clotting assay indicated that the pectin sulfate prolonged APTT and TT through inhibition of the activity of antithrombin. These results suggest that the introduction of sulfate groups into the pectin structure improved its anticoagulant activity.

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Section: Measurement Of Dsmentioning

confidence: 99%

Synthesis and anticoagulant activity of pectin sulfates

Fan

Gao

Wang

et al. 2011

J of Applied Polymer Sci

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“…The water was then distilled off under vacuum, and could be sealed into tubes and kept for counting at a later date. More recently, the tissues have been burned in a flask of oxygen containing a known volume of water as a scavenger (Schoniger, 1955(Schoniger, , 1956). This method is not very satisfactory for specimens with low specific activity, however, because of the dilution of the activity by the water added as scavenger.…”

Section: Specific Activity Measurerventsmentioning

confidence: 99%

Tritium uptake, half‐lives and radiation doses in tissues of cancer patients treated with tritiated 2‐methyl‐1: 4‐naphthaquinol diphosphate

Chipperfield

1967

Intl Journal of Cancer

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Comparisons of the uptake into tumour biopsies 30 min ajier intravenous or intraarterial injections showed that tumours of gastrointestinal origin took up signiJicantly greater amounts of the tritiated drugs than did any other group of tumours, and with other types of tumours some individual biopsies showed very high tumour specific activities afrer intra-arterial injections. The tritium in the turnour disappeared by two exponential decay processes, one with a half-life of 1.35 days and the other with a half-life of 14.4 days. The ratio of the concentration of the long-lived component to that of the short-lived component was 0.33.Tritium estimations on normal tissues taken at autopsy from patients who received only one injection of the tritiated drug showed that the biological half-life in normal tissues ranged from 5.7 days (heart) to 34.5 days (long-lived component in brain). The initial specific activity in pclg for each clkg injected ranged from 71 (long-lived component in brain) to 505 (kidney).After a single injection of 1 c of the drug per kg body weight, the greatest doses of radiation were received by the kidney (1,600 R ) , testis (1,300 R ) , liver (1,050 R ) and bruin (990 R). The lowest doses were received by skeletal muscle (39.5 R ) and bone marrow (604 R ) .The radiation dose in the tumour depends on the initial concentration and the half-life in the tumour. Initial tumour concentrations of 5-8 mclg wet tissue should give radiation doses in the therapeutic range after a single injection.

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“…Determination of the chlorine content was done according to the procedure of Schöniger with the help of a Metrohm Titroprocessor. 36,37 The phosphorus content was determined by ICP-AES on a Varian-VISTA Simultan spectrometer. Melting points were obtained on a Büchi-540 apparatus and are uncorrected.…”

Section: N Andmentioning

confidence: 99%