Die pathogenetische Bedeutung der 5α-Reduktase-Isoenzyme für die androgenetische Alopezie

Hoffmann, Rolf; Happle, Rudolf

doi:10.1007/s001050050884

Cited by 8 publications

(4 citation statements)

References 44 publications

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“…Von dem für die AGA entscheidend wichtigen Enzym 5a−Reduk− tase sind zwei Isoformen bekannt [33,34] [35,36], das heißt, das Pharmakon besitzt in therapeutischen Dosen keine Hormonwir− kung. Zur besseren Abgrenzung gegen das hormonell wirksame 17b−Estradiol sollte durchgehend der Name Alfatradiol verwen− det werden.…”

Section: Introductionunclassified

Alfatradiol (0,025 %) - Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern

Wozel¹,

Narayanan²,

Jäckel³

et al. 2005

Akt Dermatol

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Androgenetic alopecia (AGA), also referred to as male pattern baldness, is the most common cause of hair loss in both sexes in adulthood. An option for topical treatment that selectively tar− gets the metabolic pathways involved in the balding process is alfatradiol, an estrasterid without hormonal activity. In a drug monitoring study, efficacy and safety of alfatradiol (0.025 %) was assessed in 233 patients with AGA (192 women, aged 14 ± 76 years, and 41 men, aged 17 ± 56 years). After 7.5 months of treat− ment, trichograms of 112 patients (92 women, 20 men) were evaluated. Under treatment with alfatradiol the proportion of frontal anagen hair increased statistically significantly, in wom− en from 69 % to 77 % (means) and in men from 56 % to 65 %. The proportion of telogen hair decreased accordingly. In 12 % of wom− en and 21 % of men a further decline in the number of anagen hair was observed. Merely three patients (1,3 %) reported mild local adverse reactions. In conclusion, Alfatradiol appears to be ef− fective and safe in the topical treatment of AGA in both men and women.

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Section: Introductionunclassified

Alfatradiol (0,025 %) - Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern

Wozel¹,

Narayanan²,

Jäckel³

et al. 2005

Akt Dermatol

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“…Insbesondere der 5α-Reduktase,die Testosteron zu Dihydrotestosteron metabolisiert, kommt eine wichtige Rolle zu (Übersicht in [11]). Finasterid, das seit 1993 in einer Tagesdosierung von 5 mg zur Behandlung der benignen Prostatahyperplasie eingesetzt wird (Proscar ® ), ist ein kompetitiver Hemmer der Typ-II-5α-Reduktase.…”

Section: Pharmakologische Maßnahmenunclassified

Neues und Bew�hrtes in der Therapie von Haarerkrankungen

Trüeb

2003

Der Hautarzt

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Recently rational drug therapy and potent technologies have been introduced for the treatment of the most frequent hair problems, i.e. finasteride in the treatment of male pattern hair loss, and laser-assisted hair removal systems for hypertrichosis and hirsutism. Together with the availability of such treatments, high technical standards for evaluating their efficacy have been developed, e.g. computer-assisted epiluminiscence microscopy. Besides these physical aspects, life quality has also become an important issue in clinical studies, and is assessed by standardized patient questionnaires. In the treatment of hair loss, women have become reluctant about taking systemic hormones since the results of large epidemiological studies on the risks of hormonal replacement therapy have become public. Topical 17alpha-estradiol offers an alternative, though its efficacy has not been proven. The results of double-blinded, placebo-controlled studies demonstrating efficacy are yet only available for topical minoxidil. In the treatment of alopecia areata, there is no treatment that guarantees regrowth and stable growth of recovered hair. Only topical immunotherapy produces a higher remission rate that the natural evolution of disease. Scarring alopecias are not frequent but they need a careful evaluation, including scalp biopsy, for a precise diagnosis, because of irreversibility and potentially grave cosmetic consequences. The introduction of the modern broad spectrum antimycotic agents has greatly improved the management of infectious scarring alopecias. Finally, developments in hair care and anti-aging medicine are discussed, with special referral to the evolving difficulty of delineating medical science from marketing strategies in this trendy field.

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“…On the other hand, sexual steroids can be involved in the disruption of hair growth as well. In humans it has been demonstrated, that the local metabolism of testosterone (T) within the hair follicle plays a major role in the pathophysiology of male pattern baldness, also known as androgenetic alopecia (Hoffmann and Happle, 1999; Stenn and Paus, 2001).…”

Section: Introductionmentioning

confidence: 99%

Effect of Testosterone and Oestradiol‐17β on Canine Hair Follicle Culture

Robia

Mitteregger

Aichinger

et al. 2003

Journal of Veterinary Medicine Series A

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Skin biopsies were taken from four body sites (head, thorax, flank and perineum) of three male entire Beagles and the primary hair follicles were isolated. Culture conditions were established to keep the hair follicles growing for up to 7 days. Additionally, hair follicles were incubated in supplemented medium (containing insulin, transferrin, glutamine and sodium selenite) with or without the addition of testosterone (T) (1, 10 or 100 ng/ml) or oestradiol-17beta (E2beta) (0.01, 0.1 or 1 ng/ml), respectively and the daily growth of hair follicles was measured. In vitro daily growth of hair follicles from the thorax was stimulated by the low concentration of both hormones, but the growth of those from the flank was inhibited by the high concentration of both hormones. Hair follicles from the head were positively influenced by the lowest concentration of T and the medium concentration of E2beta. The daily growth of hair follicles from the perineum was not significantly influenced by either hormone.

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Die pathogenetische Bedeutung der 5α-Reduktase-Isoenzyme für die androgenetische Alopezie

Cited by 8 publications

References 44 publications

Alfatradiol (0,025 %) - Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern

Alfatradiol (0,025 %) - Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern

Neues und Bew�hrtes in der Therapie von Haarerkrankungen

Effect of Testosterone and Oestradiol‐17β on Canine Hair Follicle Culture

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