Die Pathologie der Avitaminosen und Hypervitaminosen

Studer, A.; Zbinden, G.; Uehlinger, E

doi:10.1007/978-3-662-28643-2_4

Cited by 6 publications

(3 citation statements)

References 1,158 publications

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“…It is classified by the Food and Drug Administration as a Generally Recognized as Safe (GRAS) product (21 CFR 184, 1695(21 CFR 184, , 2001). The safety of RB has been demonstrated for oral, subcutaneous, intraperitoneal and intravenous routes of administration [13][14][15][16]. Neonates undergoing phototherapy for neonatal jaundice are often temporarily RB-deficient due to the overlapping light absorption spectra of RB and bilirubin [17][18][19][20].…”

Section: Toxicology and Safetymentioning

confidence: 99%

“…In patient samples from the MIRACLE clinical trial no RB was detected in any patient sample, and only traces of LC (0.06-0.07 μmol/l) were detected 24 h after transfusion in two patient samples analyzed (4%). Comparison of a RB exposure level of 0.077 mg/kg to the reported LD 50 for intravenous RB infusion in mice of 50-100 mg/kg [15] yields a large safety factor (649-1,299). The exposure level can also be compared to the levels of RB provided in parenteral nutrition.…”

Section: Introductionmentioning

confidence: 99%

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Pathogen Reduction Technology Treatment of Platelets, Plasma and Whole Blood Using Riboflavin and UV Light

Marschner¹,

Goodrich²

2011

Transfus Med Hemother

183

186

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Bacterial contamination and emerging infections combined with increased international travel pose a great risk to the safety of the blood supply. Tests to detect the presence of infection in a donor have a ‘window period’ during which infections cannot be detected but the donor may be infectious. Agents and their transmission routes need to be recognized before specific tests can be developed. Pathogen reduction of blood components represents a means to address these concerns and is a proactive approach for the prevention of transfusion-transmitted diseases. The expectation of a pathogen reduction system is that it achieves high enough levels of pathogen reduction to reduce or prevent the likelihood of disease transmission while preserving adequate cell and protein quality. In addition the system needs to be nontoxic, non-mutagenic and should be simple to use. The Mirasol® Pathogen Reduction Technology (PRT) System for Platelets and Plasma uses riboflavin (vitamin B2) plus UV light to induce damage in nucleic acid-containing agents. The system has been shown to be effective against clinically relevant pathogens and inactivates leukocytes without significantly compromising the efficacy of the product or resulting in product loss. Riboflavin is a naturally occurring vitamin with a well-known and well-characterized safety profile. The same methodology is currently under development for the treatment of whole blood, making pathogen reduction of all blood products using one system achievable. This review gives an overview of the Mirasol PRT System, summarizing the mechanism of action, toxicology profile, pathogen reduction performance and clinical efficacy of the process.

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Section: Toxicology and Safetymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pathogen Reduction Technology Treatment of Platelets, Plasma and Whole Blood Using Riboflavin and UV Light

Marschner¹,

Goodrich²

2011

Transfus Med Hemother

183

186

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“…Nach KUNZ, KRANZ und KEIM (1967) sowie JUNGE-HULSING, RAVE, WAGNER et al (1969) kommt es bei Ratten zunachst zu ,,erheblicher Akzeleration des Bindegewebsstoffwechsels" mit stark gesteigertem Sulfat-Einbau in die Mucopolysaccharide und nachfolgend zu Kalkablagerungen. Auch in ,,normal" alternden Aorten wurde bei Mensch, Ratte, Rind, Schwein und Hund eine Anhaufung von sauren Mucopolysacchariden beobachtet (SCHALLOCK, 1958;BUDDECKE, 1960), auf die besondere Bedeutung dieser sauren Bindegewebsbestandteile fur die Gewebsverkalkung wurde immer wieder hingewiesen (HOLMAN und MCCANE, 1956;SCHALLOCK, 1958;BUDDECKE, 1960;STUDER, ZBINDEN und UEHLINGER, 1962;STUDER und REBER, 1963;KOHLER, 1964;STUNZI, 1967;KOPPEL, SCHUTZLER und HORN, 1971;KOBAYASHI, 1971;u.a.). Analog dazu fanden GERLACH und THEMAN (1965 a, b)…”

Section: Der Genaue Ablauf Der Weichgewebeverkalkungen Unter Einff Uiunclassified

Der Einfluß hoher Dosen Vitamin D3 auf den Natrium-, Kalium-, Calcium- und Wassergehalt der Aortenwand von Masthähnchen

Höppner

Schützler

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Zusammenfassung Der Natrium‐, Kalium‐, Calcium‐ und Wassergehalt wurde in der Aortenwand von 29 Tage alten Masthähnchen bestimmt, die unter gleichen Umweltbedingungen vom 7. bis zum 28. Lebenstag unterschiedliche Mengen Vitamin D3 — zwischen 52 960 und 1 536 000 IE; Kontrolltiere = Gruppe I: 750 IE — über das Futter aufgenommen hatten. Der Natrium‐ und Wassergehalt blieb unverändert. Die Kaliumkonzentration der Aortenwand sank von 161,23 ± 6,23 mval K/kg Trockensubstanz bei den Tieren der Gruppe I auf 144,70 ± 13,69 mval K/kg Trockensubstanz bei den Tieren der Gruppe V signifikant (p < 0,01) ab, jedes dieser Hähnchen hatte etwa 340 000 IE Vitamin D3 aufgenommen. Verdopplung bzw. Vervierfachung dieser Cholecalciferol‐Dosis führte nicht zu weiterer Kaliumabnahme. Beginnend von etwa 210 000 aufgenommenen IE Vitamin D3 stieg der Calciumgehalt mit der Cholecalciferolaufnahme von Gruppe zu Gruppe signifikant (p < 0,01) an; dabei trat besonders bei den höchsten Vitamin D‐Aufnahmen (Gruppe VI und VII) eine starke Vergrößerung der Streuung auf. Summary The effect of large doses of Vitamin D3 on the Na, K, Ca and water content of the aortic wall of broilers The Na, K, Ca and water content of the aortic wall of 29 days old broilers was measured. The birds were kept under constant environmental conditions from the 7th to the 28th day on doses of vitamin D3 ranging from 52,960 to 1,536,000 i. u. Control birds (Group 1) received 750 i. u. in their food. Na and water content showed no change (p < 0.01). The K concentration in the aortic wall fell significantly from 161 ± 6.23 mval K/kg. dry matter in the birds in Group 1 to 144.70 ± 13.69 mval K/dry matter in Group V where the vitamin D3 content was 340,000 i. u. Doubling and even quadrupling this vitamin D3 level produced no further fall in K. Starting at a D3 level of 210,000 i. u. the Ca content rose significantly from group to group (p < 0.01). Spread of the values was especially marked in the groups with the largest vitamin D3 supplement (Groups VI and VII). Résumé Influence de hautes doses en vitamine D3 sur le contenu en sodium, potassium, calcium et en cau de la paroi de l'aorte du coquelet d'engrais On a déterminé la quantité de sodium, de potassium, de calcium et d'eau dans la paroi de l'aorte chez des coquelets d'engrais de 29 jours qui ont reçu, dans les mêmes conditions, du 7ème au 28ème jour des doses variables de vitamine D3 (entre 52′960 à 1′536 000 UI) dans l'aliment. Animaux de contrôle = groupe I (750 UI). La quantité de sodium et d'eau resta inchangée. La concentration en potassium de la paroi de l'aorte passa de 161,23 ± 6,23 mval K/kg de substance sèche chez les animaux du groupe I à 144,70 ± 13,69 mval K/kg de substance sèche chez les animaux du groupe V (P < 0,01), chacun de ces poulets ayant absorbé environ 340′000 UI de vitamine D3. Le fait de doubler ou de quadrupler cette dose de cholecalciférol ne provoqua aucune nouvelle diminution du potassium. Avec une dose initiale de 210′000 UI de vitamine D3 absorbée, la quantité de calcium a augmenté de facon...

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Experimental Aspects of Growth Plate Disorders

Riede¹

1974

Current Topics in Pathology

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Die Pathologie der Avitaminosen und Hypervitaminosen

Cited by 6 publications

References 1,158 publications

Pathogen Reduction Technology Treatment of Platelets, Plasma and Whole Blood Using Riboflavin and UV Light

Pathogen Reduction Technology Treatment of Platelets, Plasma and Whole Blood Using Riboflavin and UV Light

Der Einfluß hoher Dosen Vitamin D3 auf den Natrium-, Kalium-, Calcium- und Wassergehalt der Aortenwand von Masthähnchen

Experimental Aspects of Growth Plate Disorders

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