Die Periarthritis humeroscapularis

Schaer, Hans

doi:10.1007/978-3-642-91091-3_4

Cited by 15 publications

(7 citation statements)

References 46 publications

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“…T h e most interesting o f the degenerative changes is the cystic degeneration reviewed. It has morphological features similar to those seen in ruptures of the tendon of the supraspinatus in the shoulder reported by SCHAER (1936). The changes are also in some respects similar to those occurring in the ruptures of different tendons reported by many investigators.…”

Section: B Histopathologic Changessupporting

confidence: 82%

“…The metaplasia of the tendinous tissue into fibrocartilage begins, however, fairly early in the midmost and deep layers. SCHAER (1936) and DEPALMA (1952) reported metaplasia of ten dinous tissue into fibrocartilage in the shoulder in connection with degen eration of the tendon of the supraspinatus. How the fibrocartilage found in different tendons and hgaments constitutes a reaction mechanism to continuous overstrain of the tissue was described by ALBERTINI (1929).…”

Section: Fig S: Tm Foci Of Degeneration In the Deepest Layer Of The mentioning

confidence: 99%

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The Surgical Anatomy and Pathology of the Supraspinous and Interspinous Ligaments of the Lumbar Spine with Special Reference to Ligament Ruptures

Rissanen

1960

Acta Orthopaedica Scandinavica

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Section: B Histopathologic Changessupporting

confidence: 82%

Section: Fig S: Tm Foci Of Degeneration In the Deepest Layer Of The mentioning

confidence: 99%

The Surgical Anatomy and Pathology of the Supraspinous and Interspinous Ligaments of the Lumbar Spine with Special Reference to Ligament Ruptures

Rissanen

1960

Acta Orthopaedica Scandinavica

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“…Schaer 10 found that 25% of their patients with frozen shoulder had Dupuytren's contracture. We found 58% of our patients with frozen shoulder had evidence of palmar contracture, usually in the form of a pit or nodule, and more rarely a band of Dupuytren's disease.…”

Section: Associationsmentioning

confidence: 98%

(ii) Frozen shoulder

Bunker

2011

Orthopaedics and Trauma

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“…15 Both of these conditions involve similar fibrotic mechanisms (of the shoulder joint capsule in the case of frozen shoulder), the laying down of a collagen-rich ECM, and the involvement of myofibroblast-mediated contraction. 16,17 Although DD and frozen shoulder have different natural histories (the former a progressive disease, the latter usually self-limiting and resolving in time), they may well share common pathways leading to contracture. 16 The MMP inhibitors that cause the musculoskeletal syndrome are pan-MMP inhibitors, showing an approximately nanomolar (or lower) inhibition constant against many of the MMPs tested.…”

mentioning

confidence: 99%

A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease

Johnston

Chojnowski

Davidson

et al. 2007

The Journal of Hand Surgery

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Purpose: Dupuytren's disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix macromolecules. A number of broad-spectrum matrix metalloproteinase inhibitors, used in cancer clinical trials, caused side effects of DD-like contractures. We tested the hypothesis that changes in the expression of specific metalloproteinases underlie or contribute to the fibrosis and contracture seen in DD. Methods: We collected tissue from patients with DD and used normal palmar fascia as a control. We profiled the expression of the entire matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinases (TIMP), and a disintegrin and metalloproteinase domain with thrombospondin motif (ADAMTS) gene families in these tissues using real-time reversetranscription polymerase chain reaction. Results: A number of metalloproteinases and inhibitors are regulated in DD. The expression of 3 key collagenases, MMP1, MMP13, and MMP14 is increased significantly in the DD nodule, as is the expression of the collagen biosynthetic enzyme ADAMTS14. The expression of MMP7, an enzyme with broad substrate specificity, is increased in the DD nodule and remains equally expressed in the DD cord. TIMP1 expression is increased significantly in DD nodule compared with normal palmar fascia. Conclusions: This study measured the expression of all MMP, ADAMTS, and TIMP genes in DD. Contraction and fibrosis may result from: (1) increased collagen biosynthesis mediated by increased ADAMTS-14; (2) an increased level of TIMP-1 blocking MMP-1-and MMP-13-mediated collagenolysis; and (3) contraction enabled by MMP-14 -mediated pericellular collagenolysis (and potentially MMP-7), which may escape inhibition by TIMP-1. The complete expression profile will provide a knowledge-based approach to novel therapeutics targeting these genes. (J Hand Surg 2007;32A:343-351.

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Die Periarthritis humeroscapularis

Cited by 15 publications

References 46 publications

The Surgical Anatomy and Pathology of the Supraspinous and Interspinous Ligaments of the Lumbar Spine with Special Reference to Ligament Ruptures

The Surgical Anatomy and Pathology of the Supraspinous and Interspinous Ligaments of the Lumbar Spine with Special Reference to Ligament Ruptures

(ii) Frozen shoulder

A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease

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