Die primär chronische interstitielle Nephritis (Schluß¹)

Further Study of the Mechanism of Reduction of Erythrocyte Survival Time in Phenacetin Habitués and its Relation to “Phenacetin Kidney Disorders”

“…Generally, a relationship has been found between the extent of the damage provoked by phenacetin and the size of dose and duration of ingestion (8,9,15,17,29). However, some factor seems to exist which is not consistent with the theory that a simple, toxic damage of long duration caused by the breakdown products of phenacetin (at any rate alone) should result in nephropathy.…”

“…Local, toxic damage to the kidney tissue caused by the breakdown products of phenacetin, precipitation into the tubuli of methaemoglobin, sulphhaemoglobin, etc. (2, 9,11,12,23).…”

Phenacetin and Renal Damage at a Swedish Factory

“…The drug was considered to have largely the same antipyretic and analgesic effect as the parent substances, but did not cause methaemoglobin to form to the same extent (9). In 1953, however, a report by Spiihler & Zollinger (47) of a connection between chronic interstitial nephritis and excessive consumption of phenacetin gave rise to intensive research in Switzerland, Denmark and other European countries (6,11,13,23,17,25,31). An association between renal papillary necrosis and excessive consumption of phenacetin over long periods has also been demonstrated (3, 16,24).…”