Die Problematik der Kontrastmittelüberempfindlichkeit

Ring, J

doi:10.1055/s-0028-1103939

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…It is surprising that the premedication with an H(-antagonist or with prednisolone showed so little ef fect, since this is the most widely used prophylactic re gimen [21,26,28,35]. In this study prednisolone was given in a dose of 250 mg intravenously 5 min prior to RCM infusion.…”

Section: Discussionmentioning

confidence: 99%

“…The infusion of ionic radiographic contrast media (RCM) is connected with a certain risk of adverse reactions which occur at a frequency of 5-15% [2,5,26,27,31]. Lethal reactions are estimated to occur with a frequency of 1:10,000-1:40,000 [26,31].…”

Section: Introductionmentioning

confidence: 99%

“…Lethal reactions are estimated to occur with a frequency of 1:10,000-1:40,000 [26,31]. Clin ically most of the RCM-induced adverse reactions are anaphylactoid reactions, i.e., according to our defini tion, they manifest with clinical symptoms of great similarity to those of anaphylactic reactions without exact knowledge about the pathomechanism involved [24].…”

Section: Introductionmentioning

confidence: 99%

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Prevention of Anaphylactoid Reactions after Radiographic Contrast Media Infusion by Combined Histamine H1- and H2-Receptor Antagonists: Results of a Prospective Controlled Trial

Ring

Rothenberger

Clauß³

1985

Int Arch Allergy Immunol

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In a prospective randomized trial, 800 patients undergoing intravenous urography were pretreated with either intravenous prednisolone (group I), the H₁-antagonist clemastin (group II), a combination of clemastin and the H₁-antagonist cimetidine (group III) or 0.9% saline (group IV). There was an overall incidence of 18–19% side reactions, when subjective and objective symptoms were regarded together. There was no significant difference between the four groups in the total incidence. The same applies when considering subjective side effects including the symptom ‘heat sensation’ that occurred in 10–12% of all patients. However, when side effects excluding the symptom ‘heat sensation’ were regarded and the individual groups were compared, there was a significant difference in frequency between the control group (12%) and the combined H₁/H₂ group (6%). Prednisolone and clemastin did not produce a significant reduction of side effects. The combined application of histamine H₁- and H₂-antagonists might be useful in prophylaxis of radiographic contrast media-induced adverse reactions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevention of Anaphylactoid Reactions after Radiographic Contrast Media Infusion by Combined Histamine H1- and H2-Receptor Antagonists: Results of a Prospective Controlled Trial

Ring

Rothenberger

Clauß³

1985

Int Arch Allergy Immunol

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“…The use of ionic radiographic contrast media (RCM) is connected with an incidence of anaphylactoid reactions at a frequency of 5 15%; lethal reactions arc estimated to occur in 1:10 000-1:40 000 patients [24,25]. Although the pathophysiology of RCM-reactions has by no means been established, there is increasing evidence ofa direct mediator releasing capacity of substances such as histamine.…”

Section: Radiographic Contrast Media Reactionsmentioning

confidence: 99%

H₁‐ and H₂‐antagonists in allergic and pseudoallergic diseases

Ring¹,

Behrendt²

1990

Clin Experimental Allergy

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Although known for more than 80 years, histamine still remains a fascinating substance for allergy research. Histamine antagonists have been in clinical use since 1942. The classical H1-antagonists with sedative side-effects have been more or less replaced by newer non-sedating H1-antagonists; the role of H2-receptors in allergic diseases is still controversial. There, are however, increasing reports of beneficial effects of H2-antagonists, mostly in combination with H1-antagonists, in a variety of allergic and pseudoallergic conditions such as chronic urticaria, anaphylactoid reactions due to colloid volume substitutes, opioid analgesics and radiographic contrast media. The combined use of H1- and H2-antagonists might not only act as specific histamine antagonism but exert a mast cell stabilizing effect, as demonstrated in animal experiments and some clinical studies. Future research will show whether the combined use of H1- and H2-antagonists will become a routine therapeutic procedure in allergy therapy.

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