Die S3-Leitlinie zur Diagnostik und Therapie der Zwangsstörungen

Kordon, Andreas; Lotz-Rambaldi, Winfried; Muche-Borowski, Cathleen; Zurowski, Bartosz; Hohagen, Fritz

doi:10.1055/s-0034-1376927

Cited by 10 publications

(5 citation statements)

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“…The results of the pilot study served to revise the MCT-OCD, and this revised version will be evaluated in a randomized controlled trial with an outpatient sample in the proposed study, which may allow more robust conclusions about the efficacy of the intervention. The MCT-OCD in a group format comes with the general advantages of group therapy (e.g., patients are able to share their thoughts with others who have similar symptoms and obstacles), which has already been shown to be very helpful for patients with OCD for CBT groups [51].…”

Section: Metacognitive Training For Patients With Ocdmentioning

confidence: 99%

Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial

et al. 2020

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Background A high number of patients with obsessive-compulsive disorder (OCD) do not receive cognitive-behavioral therapy with exposure and response prevention, which is the most effective treatment for OCD. Therefore, Metacognitive Training for OCD (MCT-OCD) was developed, which is a structured group therapy aiming at the modification of dysfunctional (meta-)cognitive biases, beliefs and coping styles. It can be administered by less trained personnel, thus may reach a higher number of patients. An uncontrolled pilot study (MCT-OCD pilot version) provided first evidence that the training is highly accepted by patients; OC symptoms decreased with a high effect size (η2partial = 0.50). The aim of the present study is to address the shortcomings of the pilot study (e.g., no control group) and to assess the efficacy of the revised version of the MCT-OCD in the framework of a randomized controlled trial. Methods Eighty patients with OCD will be recruited. After a blinded assessment at baseline (−t1), patients will be randomly assigned either to the intervention group (MCT-OCD; n = 40) or to a care as usual control group (n = 40). The MCT-OCD aims to enhance patients’ metacognitive competence in eight modules by addressing dysfunctional (meta-)cognitive biases and beliefs associated with OCD (e.g., intolerance of uncertainty). After 8 weeks, patients will be invited to a post assessment (t1), and then they will receive a follow-up online questionnaire 3 months following t1 (t2). The primary outcome is the Y-BOCS total score, and the secondary outcomes include the HDRS, OCI-R, OBQ-44, MCQ-30, WHOQOL-BREF, BDI-II, and subjective appraisal ratings of the MCT-OCD. We expect that OC symptoms will decrease more in the intervention group compared with the care as usual control group from –t1 to t1 and that treatment gains will be maintained until t2. Discussion The planned study is the first to investigate the MCT-OCD, a promising new treatment, in a randomized controlled trial. The MCT-OCD may help to overcome existing treatment barriers for patients with OCD. Trial registration German Registry for Clinical Studies (DRKS00013539), 22.02.2018.

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Section: Metacognitive Training For Patients With Ocdmentioning

confidence: 99%

Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial

et al. 2020

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“…It has a lifetime prevelence of about 1.3% (Fawcett et al, 2020) and often takes a chronic course if untreated (van Oudheusden et al, 2018). Cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) and pharmacotherapy with serotonin‐reuptake inhibitors are recommended in national and international guidelines (Kordon et al, 2014; National Institute for Health and Care Excellence [NICE], 2005). However, in clinical practice, ERP is often not used (Böhm et al, 2008; Külz et al, 2010) or incorrectly applied (Gillihan et al, 2012; Hipol & Deacon, 2013).…”

Section: Introductionmentioning

confidence: 99%

Mixed results for exposure and response prevention therapy in mixed reality for patients with contamination‐related obsessive‐compulsive disorder: A randomized controlled pilot study

et al. 2023

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IntroductionTechnology‐supported exposure and response prevention (ERP) for patients with obsessive‐compulsive disorder (OCD) as tested in clinical research, holds promise but also has limitations. The present study aims to overcome these limitations by using mixed reality for ERP (MERP). The objectives of this pilot study were to evaluate the safety, feasibility, and acceptance of MERP and to identify possible obstacles.MethodsTwenty inpatients with contamination‐related OCD were recruited and randomized to two conditions: MERP (six sessions in 3 weeks) and care as usual treatment. Patients were assessed before treatment (baseline), after the 3‐week intervention period (post), as well as 3 months after post assessment (follow‐up) regarding symptomatology (Y‐BOCS).ResultsResults showed a similar reduction in symptomatology in both groups from baseline to post. Regarding safety, no clinically significant deterioration was detected in the MERP group. Patients' evaluation of the MERP was heterogeneous. The qualitative feedback provided helpful indications for further development of the software. Sense of presence was below the midpoint of the scales.ConclusionThis is the first study evaluating a MERP for patients with OCD that shows cautious evidence for the acceptance and safety of MERP. The results of the subjective evaluation suggest revisions of the software.

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“…The first-line psychological treatment is cognitive-behavioral therapy (CBT) with exposure and response prevention (Ex/RP; Skapinakis et al, 2016), which has shown to be effective with large effect sizes (Hedges' g = 1.31; Öst et al, 2015). Group settings are increasingly recommended to serve the high number of patients and reduce treatment costs (Kordon et al, 2014;Sousa et al, 2006). A recent metaanalysis (Schwartze et al, 2016) showed that group CBT for OCD was as effective as individual therapy and pharmacotherapy and superior to wait-list control (Hedges' g = 0.97, 95% CI 0.58; 1.37, p < .001, k = 4).…”

Section: Introductionmentioning

confidence: 99%

The Metacognitive Training for obsessive-compulsive disorder: A pilot study

et al. 2020

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More than 50% of patients with obsessive-compulsive disorder (OCD) do not receive first-line psychological treatment such as cognitive-behavioral therapy with exposure and response prevention. To narrow this treatment gap, there is an urgent need for therapies that are easy to disseminate and highly accepted by patients. The aim of the present pilot study was to evaluate the effectiveness of the Metacognitive Group Training for OCD (MCT-OCD). Fifty patients with OCD participated in the MCT-OCD for 4 weeks during their inpatient stay in a single-arm pilot trial. Patients were assessed before and after the intervention and filled out an online survey 6 months after post assessment. Results showed a decrease in obsessive compulsive symptoms according to the Yale-Brown Obsessive Compulsive Scale (primary outcome) from baseline to post assessment with a large effect size. Symptom reduction remained stable over 6 months and was positively correlated with appraisal ratings of the training. The reduction in frequency of obsessive compulsive symptoms, distress due to obsessive compulsive symptoms, cognitive biases, and depressive symptoms remained stable over 6 months after the intervention. Our findings tentatively imply that the MCT-OCD is a promising treatment for OCD patients. A randomized controlled trial is thus warranted to further clarify the efficacy of the MCT-OCD. Trial Registration: German Clinical Trials Register (DRKS-ID: DRKS00012531), date of registration: 16.06.2017.

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Die S3-Leitlinie zur Diagnostik und Therapie der Zwangsstörungen

Cited by 10 publications

References 0 publications

Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial

Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial

Mixed results for exposure and response prevention therapy in mixed reality for patients with contamination‐related obsessive‐compulsive disorder: A randomized controlled pilot study

The Metacognitive Training for obsessive-compulsive disorder: A pilot study

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