Die solitäre Nierenzellkarzinommetastase in der Schilddrüse

Abstract

We investigated the usefulness of thyroidectomy for solitary metastases from renal cell carcinomas in ten patients. In the absence of postoperative morbidity and mortality, a mean survival time of 3.4 years was observed. Subsequently, four patients developed intracerebral metastases. Swelling of the neck and the discovery of a nodule in the thyroid of patients who have undergone nephrectomy for renal cell carcinoma should raise suspicion of a metastasis, possibly after a long latency period. With the aid of modern immunohistochemical methods, renal cell carcinoma metastasis can now be identified unequivocally, with differentiation from a primary follicular carcinoma of the thyroid rendered possible by a combination of TTF-1, thyroglobulin, and CD 10. In the event of a solitary lesion with no extrathyroidal tumour manifestation, an R0 resection of the metastasis should always be attempted. If tumour dissemination has occurred, palliative measures and endoscopic intervention (e.g. placement of an endotracheal stent) with the aim of improving quality of life by preventing obstruction of the airways are justified.

A single thyroid nodule revealing early metastases from clear cell renal carcinoma: case report and review of literature

“…In cases of aggressive primary RCC and diffuse metastases, the prognosis is poor and thyroid surgery is only recommended with palliative intent with the aim of improving quality of life by preventing airway obstruction [16]. However, for those patients with an indolent primary lesion and disease confined to the thyroid gland without significant extra-thyroid extension, surgery with curative intent is possible and may offer good survival rates and long disease-free intervals [6], [17].…”

Late-Onset Metastasis of Renal Cell Carcinoma into a Hot Thyroid Nodule: An Uncommon Finding Not to Be Overlooked

“…The recent literature review by Chung et al [ 4 ] of 372 cases, 180 of which (48%) with thyroid metastasis from CCRC, shows that metastases to the thyroid gland are solitary in up to 40% of patients. Other reports on smaller numbers of patients confirm that metastases from CCRC are mostly solitary [ 10 ].…”

Metastasen in der Schilddrüse

“…Das Nierenzellkarzinom metastasiert am häufigsten in Lunge, Knochen und Leber (17,18,25,26). Isolierte Metastasen in der Schilddrüse sind selten (14,17,18). In den vergangenen zehn Jahren wurde in 14 Publikationen über 77 Patienten mit Schilddrüsenmetastasen berichtet (ǠTab.…”